Search Results

Overview

Uniprot IDP53675
Protein NameClathrin heavy chain 2
Gene NameCLTCL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
456 EKWLKEDKLECSEEL
506 QKIVLYAKKVGYTPD
737 KYIQAACKTGQIKEV

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity)

Protein Sequence

10 MAQILPVRFQ 20 EHFQLQNLGI 30 NPANIGFSTL 40 TMESDKFICI 50 REKVGEQAQV 60 TIIDMSDPMA 70 PIRRPISAES 80 AIMNPASKVI 90 ALKAGKTLQI 100 FNIEMKSKMK 110 AHTMAEEVIF 120 WKWVSVNTVA 130 LVTETAVYHW 140 SMEGDSQPMK 150 MFDRHTSLVG 160 CQVIHYRTDE 170 YQKWLLLVGI 180 SAQQNRVVGA 190 MQLYSVDRKV 200 SQPIEGHAAA 210 FAEFKMEGNA 220 KPATLFCFAV 230 RNPTGGKLHI 240 IEVGQPAAGN 250 QPFVKKAVDV 260 FFPPEAQNDF 270 PVAMQIGAKH 280 GVIYLITKYG 290 YLHLYDLESG 300 VCICMNRISA 310 DTIFVTAPHK 320 PTSGIIGVNK 330 KGQVLSVCVE 340 EDNIVNYATN 350 VLQNPDLGLR 360 LAVRSNLAGA 370 EKLFVRKFNT 380 LFAQGSYAEA 390 AKVAASAPKG 400 ILRTRETVQK 410 FQSIPAQSGQ 420 ASPLLQYFGI 430 LLDQGQLNKL 440 ESLELCHLVL 450 QQGRKQLLEK 460 WLKEDKLECS 470 EELGDLVKTT 480 DPMLALSVYL 490 RANVPSKVIQ 500 CFAETGQFQK 510 IVLYAKKVGY 520 TPDWIFLLRG 530 VMKISPEQGL 540 QFSRMLVQDE 550 EPLANISQIV 560 DIFMENSLIQ 570 QCTSFLLDAL 580 KNNRPAEGLL 590 QTWLLEMNLV 600 HAPQVADAIL 610 GNKMFTHYDR 620 AHIAQLCEKA 630 GLLQQALEHY 640 TDLYDIKRAV 650 VHTHLLNPEW 660 LVNFFGSLSV 670 EDSVECLHAM 680 LSANIRQNLQ 690 LCVQVASKYH 700 EQLGTQALVE 710 LFESFKSYKG 720 LFYFLGSIVN 730 FSQDPDVHLK 740 YIQAACKTGQ 750 IKEVERICRE 760 SSCYNPERVK 770 NFLKEAKLTD 780 QLPLIIVCDR 790 FGFVHDLVLY 800 LYRNNLQRYI 810 EIYVQKVNPS 820 RTPAVIGGLL 830 DVDCSEEVIK 840 HLIMAVRGQF 850 STDELVAEVE 860 KRNRLKLLLP 870 WLESQIQEGC 880 EEPATHNALA 890 KIYIDSNNSP 900 ECFLRENAYY 910 DSSVVGRYCE 920 KRDPHLACVA 930 YERGQCDLEL 940 IKVCNENSLF 950 KSEARYLVCR 960 KDPELWAHVL 970 EETNPSRRQL 980 IDQVVQTALS 990 ETRDPEEISV 1000 TVKAFMTADL 1010 PNELIELLEK 1020 IVLDNSVFSE 1030 HRNLQNLLIL 1040 TAIKADRTRV 1050 MEYISRLDNY 1060 DALDIASIAV 1070 SSALYEEAFT 1080 VFHKFDMNAS 1090 AIQVLIEHIG 1100 NLDRAYEFAE 1110 RCNEPAVWSQ 1120 LAQAQLQKDL 1130 VKEAINSYIR 1140 GDDPSSYLEV 1150 VQSASRSNNW 1160 EDLVKFLQMA 1170 RKKGRESYIE 1180 TELIFALAKT 1190 SRVSELEDFI 1200 NGPNNAHIQQ 1210 VGDRCYEEGM 1220 YEAAKLLYSN 1230 VSNFARLAST 1240 LVHLGEYQAA 1250 VDNSRKASST 1260 RTWKEVCFAC 1270 MDGQEFRFAQ 1280 LCGLHIVIHA 1290 DELEELMCYY 1300 QDRGYFEELI 1310 LLLEAALGLE 1320 RAHMGMFTEL 1330 AILYSKFKPQ 1340 KMLEHLELFW 1350 SRVNIPKVLR 1360 AAEQAHLWAE 1370 LVFLYDKYEE 1380 YDNAVLTMMS 1390 HPTEAWKEGQ 1400 FKDIITKVAN 1410 VELCYRALQF 1420 YLDYKPLLIN 1430 DLLLVLSPRL 1440 DHTWTVSFFS 1450 KAGQLPLVKP 1460 YLRSVQSHNN 1470 KSVNEALNHL 1480 LTEEEDYQGL 1490 RASIDAYDNF 1500 DNISLAQQLE 1510 KHQLMEFRCI 1520 AAYLYKGNNW 1530 WAQSVELCKK 1540 DHLYKDAMQH 1550 AAESRDAELA 1560 QKLLQWFLEE 1570 GKRECFAACL 1580 FTCYDLLRPD 1590 MVLELAWRHN 1600 LVDLAMPYFI 1610 QVMREYLSKV 1620 DKLDALESLR 1630 KQEEHVTEPA 1640 PLVFDFDGHE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030130 clathrin coat of trans-Golgi network vesicle
Cellular Component GO:0071439 clathrin complex
Cellular Component GO:0045334 clathrin-coated endocytic vesicle
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0030135 coated vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005770 late endosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0097443 sorting endosome
Cellular Component GO:0005819 spindle
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0032051 clathrin light chain binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.