Search Results
Overview
| Uniprot ID | P53678 |
|---|---|
| Protein Name | AP-3 complex subunit mu-2 |
| Gene Name | Ap3m2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 398 | RLDMYGEKYKPFKGI |
Function
Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity)
Protein Sequence
10
MIHSLFLINS
20
AGDIFLEKHW
30
KSVVSRSVCD
40
YFFEAQERAT
50
EAENVPPVIP
60
TPHHYLLSVY
70
RHKIFFVAVI
80
QTEVPPLFVI
90
EFLHRVVDTF
100
QDYFGVCSEP
110
VIKDNVVVVY
120
EVLEEMLDNG
130
FPLATESNIL
140
KELIKPPTIL
150
RTVVNTITGS
160
TNVGDQLPTG
170
QLSVVPWRRT
180
GVKYTNNEAY
190
FDVVEEIDAI
200
IDKSGSTVTA
210
EIQGVIDACV
220
KLTGMPDLTL
230
SFMNPRLLDD
240
VSFHPCVRFK
250
RWESERILSF
260
IPPDGNFRLL
270
SYHVSAQNLV
280
AIPVYVKHSI
290
SFRDSGSLGR
300
FEITVGPKQT
310
MGKTIEGVTV
320
TSQMPKGVLN
330
MSLTPSQGTH
340
TFDPVTKMLS
350
WDVGKINPQK
360
LPSLKGTMGL
370
QVGASKPDEN
380
PTINLQFKIQ
390
QLAISGLKVN
400
RLDMYGEKYK
410
PFKGIKYMTK
AGKFQVRT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030121 | AP-1 adaptor complex |
| Biological Process | GO:0008089 | anterograde axonal transport |
| Biological Process | GO:0048490 | anterograde synaptic vesicle transport |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0006896 | Golgi to vacuole transport |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0007269 | neurotransmitter secretion |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0035615 | clathrin adaptor activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.