Search Results
Overview
| Uniprot ID | P54001 |
|---|---|
| Protein Name | Prolyl 4-hydroxylase subunit alpha-1 |
| Gene Name | P4ha1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 150 | LDTNTISKGNLPGVK |
| 157 | KGNLPGVKHKSFLTA |
| 159 | NLPGVKHKSFLTAED |
| 229 | DKALLLTKKLLELDP |
| 230 | KALLLTKKLLELDPE |
| 276 | QKTTPKKKGIAVDYL |
| 299 | LCRGEGIKMTPRRQK |
| 320 | HDGNRNPKFILAPAK |
| 372 | VHDPETGKLTTAQYR |
| 382 | TAQYRVSKSAWLSGY |
| 43 | KDLVTSLKDYIKAEE |
| 435 | PHFDFARKDEPDAFR |
| 510 | CPVLVGNKWVSNKWL |
| 515 | GNKWVSNKWLHERGQ |
| 52 | YIKAEEDKLEQIKKW |
| 57 | EDKLEQIKKWAEKLD |
| 72 | RLTSTATKDPEGFVG |
Function
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins
Protein Sequence
10
MIWGVLMMGI
20
LLPQCSAHPG
30
FFTSIGQMTD
40
LIHNEKDLVT
50
SLKDYIKAEE
60
DKLEQIKKWA
70
EKLDRLTSTA
80
TKDPEGFVGH
90
PVNAFKLMKR
100
LNTEWSELEN
110
LILKDMSDGF
120
ISNLTIQRQY
130
FPNDEDQVGA
140
AKALFRLQDT
150
YNLDTNTISK
160
GNLPGVKHKS
170
FLTAEDCFEL
180
GKVAYTEADY
190
YHTELWMEQA
200
LMQLEEGEMS
210
TVDKVSVLDY
220
LSYAVYQQGD
230
LDKALLLTKK
240
LLELDPEHQR
250
ANGNLVYFEY
260
IMSKEKDANK
270
SASGDQSDQK
280
TTPKKKGIAV
290
DYLPERQKYE
300
MLCRGEGIKM
310
TPRRQKRLFC
320
RYHDGNRNPK
330
FILAPAKQED
340
EWDKPRIIRF
350
HDIISDAEIE
360
IVKDLAKPRL
370
SRATVHDPET
380
GKLTTAQYRV
390
SKSAWLSGYE
400
DPVVSRINMR
410
IQDLTGLDVS
420
TAEELQVANY
430
GVGGQYEPHF
440
DFARKDEPDA
450
FRELGTGNRI
460
ATWLFYMSDV
470
SAGGATVFPE
480
VGASVWPKKG
490
TAVFWYNLFA
500
SGEGDYSTRH
510
AACPVLVGNK
520
WVSNKWLHER
530
GQEFRRPCTL
SELE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0016222 | procollagen-proline 4-dioxygenase complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0031418 | L-ascorbic acid binding |
| Molecular Function | GO:0004656 | procollagen-proline 4-dioxygenase activity |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.