Search Results

Overview

Uniprot IDP54071
Protein NameIsocitrate dehydrogenase [NADP], mitochondrial
Gene NameIdh2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
112 QKYSVAVKCATITPD
127 EARVEEFKLKKMWKS
133 FKLKKMWKSPNGTIR
155 FREPIICKNIPRLVP
166 RLVPGWTKPITIGRH
180 HAHGDQYKATDFVVD
193 VDRAGTFKLVFTPKD
199 FKLVFTPKDGSSAKE
243 FQYSIQKKWPLYLST
256 STKNTILKAYDGRFK
272 IFQEIFDKHYKTDFD
275 EIFDKHYKTDFDKNK
280 HYKTDFDKNKIWYEH
282 KTDFDKNKIWYEHRL
299 DMVAQVLKSSGGFVW
360 RHYREHQKGRPTSTN
384 RGLEHRGKLDGNQDL
413 VESGAMTKDLAGCIH
426 IHGLSNVKLNEHFLN
45 HYAEKRIKVEKPVVE
48 EKRIKVEKPVVEMDG
69 IWQFIKEKLILPHVD

Function

Plays a role in intermediary metabolism and energy production (PubMed:8867815). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:8867815)

Protein Sequence

10 MAGYLRAVSS 20 LCRASGSART 30 WAPAALTVPS 40 WPEQPRRHYA 50 EKRIKVEKPV 60 VEMDGDEMTR 70 IIWQFIKEKL 80 ILPHVDVQLK 90 YFDLGLPNRD 100 QTNDQVTIDS 110 ALATQKYSVA 120 VKCATITPDE 130 ARVEEFKLKK 140 MWKSPNGTIR 150 NILGGTVFRE 160 PIICKNIPRL 170 VPGWTKPITI 180 GRHAHGDQYK 190 ATDFVVDRAG 200 TFKLVFTPKD 210 GSSAKEWEVY 220 NFPAGGVGMG 230 MYNTDESISG 240 FAHSCFQYSI 250 QKKWPLYLST 260 KNTILKAYDG 270 RFKDIFQEIF 280 DKHYKTDFDK 290 NKIWYEHRLI 300 DDMVAQVLKS 310 SGGFVWACKN 320 YDGDVQSDIL 330 AQGFGSLGLM 340 TSVLVCPDGK 350 TIEAEAAHGT 360 VTRHYREHQK 370 GRPTSTNPIA 380 SIFAWTRGLE 390 HRGKLDGNQD 400 LIRFAQTLEK 410 VCVQTVESGA 420 MTKDLAGCIH 430 GLSNVKLNEH 440 FLNTTDFLDT 450 IKSNLDRALG KQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0004450 isocitrate dehydrogenase (NADP+) activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0006097 glyoxylate cycle
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0006741 NADP+ biosynthetic process
Biological Process GO:0006739 NADP+ metabolic process
Biological Process GO:1903976 negative regulation of glial cell migration
Biological Process GO:0060253 negative regulation of glial cell proliferation
Biological Process GO:1904465 negative regulation of matrix metallopeptidase secretion
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.