Search Results

Overview

Uniprot IDP54136
Protein NameArginine--tRNA ligase, cytoplasmic
Gene NameRARS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
131 MLKTKEQKVNPREIA
153 PDNECIEKVEIAGPG
205 FSSPNIAKEMHVGHL
393 TSDLAAIKQRLFEEK
504 SVAYGCIKYADLSHN
60 YRLNILRKSLQAERN

Function

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684)

Protein Sequence

10 MDVLVSECSA 20 RLLQQEEEIK 30 SLTAEIDRLK 40 NCGCLGASPN 50 LEQLQEENLK 60 LKYRLNILRK 70 SLQAERNKPT 80 KNMINIISRL 90 QEVFGHAIKA 100 AYPDLENPPL 110 LVTPSQQAKF 120 GDYQCNSAMG 130 ISQMLKTKEQ 140 KVNPREIAEN 150 ITKHLPDNEC 160 IEKVEIAGPG 170 FINVHLRKDF 180 VSEQLTSLLV 190 NGVQLPALGE 200 NKKVIVDFSS 210 PNIAKEMHVG 220 HLRSTIIGES 230 ISRLFEFAGY 240 DVLRLNHVGD 250 WGTQFGMLIA 260 HLQDKFPDYL 270 TVSPPIGDLQ 280 VFYKESKKRF 290 DTEEEFKKRA 300 YQCVVLLQGK 310 NPDITKAWKL 320 ICDVSRQELN 330 KIYDALDVSL 340 IERGESFYQD 350 RMNDIVKEFE 360 DRGFVQVDDG 370 RKIVFVPGCS 380 IPLTIVKSDG 390 GYTYDTSDLA 400 AIKQRLFEEK 410 ADMIIYVVDN 420 GQSVHFQTIF 430 AAAQMIGWYD 440 PKVTRVFHAG 450 FGVVLGEDKK 460 KFKTRSGETV 470 RLMDLLGEGL 480 KRSMDKLKEK 490 ERDKVLTAEE 500 LNAAQTSVAY 510 GCIKYADLSH 520 NRLNDYIFSF 530 DKMLDDRGNT 540 AAYLLYAFTR 550 IRSIARLANI 560 DEEMLQKAAR 570 ETKILLDHEK 580 EWKLGRCILR 590 FPEILQKILD 600 DLFLHTLCDY 610 IYELATAFTE 620 FYDSCYCVEK 630 DRQTGKILKV 640 NMWRMLLCEA 650 VAAVMAKGFD 660 ILGIKPVQRM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0034618 arginine binding
Molecular Function GO:0004814 arginine-tRNA ligase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006420 arginyl-tRNA aminoacylation
Biological Process GO:0006418 tRNA aminoacylation for protein translation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.