Search Results

Overview

Uniprot IDP54198
Protein NameProtein HIRA
Gene NameHIRA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
574 SRFTERSKATPGAPA
600 LKEQNLVKELRPRDL

Function

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit

Protein Sequence

10 MKLLKPTWVN 20 HNGKPIFSVD 30 IHPDGTKFAT 40 GGQGQDSGKV 50 VIWNMSPVLQ 60 EDDEKDENIP 70 KMLCQMDNHL 80 ACVNCVRWSN 90 SGMYLASGGD 100 DKLIMVWKRA 110 TYIGPSTVFG 120 SSGKLANVEQ 130 WRCVSILRNH 140 SGDVMDVAWS 150 PHDAWLASCS 160 VDNTVVIWNA 170 VKFPEILATL 180 RGHSGLVKGL 190 TWDPVGKYIA 200 SQADDRSLKV 210 WRTLDWQLET 220 SITKPFDECG 230 GTTHVLRLSW 240 SPDGHYLVSA 250 HAMNNSGPTA 260 QIIEREGWKT 270 NMDFVGHRKA 280 VTVVKFNPKI 290 FKKKQKNGSS 300 AKPSCPYCCC 310 AVGSKDRSLS 320 VWLTCLKRPL 330 VVIHELFDKS 340 IMDISWTLNG 350 LGILVCSMDG 360 SVAFLDFSQD 370 ELGDPLSEEE 380 KSRIHQSTYG 390 KSLAIMTEAQ 400 LSTAVIENPE 410 MLKYQRRQQQ 420 QQLDQKSAAT 430 REMGSATSVA 440 GVVNGESLED 450 IRKNLLKKQV 460 ETRTADGRRR 470 ITPLCIAQLD 480 TGDFSTAFFN 490 SIPLSGSLAG 500 TMLSSHSSPQ 510 LLPLDSSTPN 520 SFGASKPCTE 530 PVVAASARPA 540 GDSVNKDSMN 550 ATSTPAALSP 560 SVLTTPSKIE 570 PMKAFDSRFT 580 ERSKATPGAP 590 ALTSMTPTAV 600 ERLKEQNLVK 610 ELRPRDLLES 620 SSDSDEKVPL 630 AKASSLSKRK 640 LELEVETVEK 650 KKKGRPRKDS 660 RLMPVSLSVQ 670 SPAALTAEKE 680 AMCLSAPALA 690 LKLPIPSPQR 700 AFTLQVSSDP 710 SMYIEVENEV 720 TVVGGVKLSR 730 LKCNREGKEW 740 ETVLTSRILT 750 AAGSCDVVCV 760 ACEKRMLSVF 770 STCGRRLLSP 780 ILLPSPISTL 790 HCTGSYVMAL 800 TAAATLSVWD 810 VHRQVVVVKE 820 ESLHSILAGS 830 DMTVSQILLT 840 QHGIPVMNLS 850 DGKAYCFNPS 860 LSTWNLVSDK 870 QDSLAQCADF 880 RSSLPSQDAM 890 LCSGPLAIIQ 900 GRTSNSGRQA 910 ARLFSVPHVV 920 QQETTLAYLE 930 NQVAAALTLQ 940 SSHEYRHWLL 950 VYARYLVNEG 960 FEYRLREICK 970 DLLGPVHYST 980 GSQWESTVVG 990 LRKRELLKEL 1000 LPVIGQNLRF 1010 QRLFTECQEQ LDILRDK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0000417 HIR complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0042393 histone binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:1902275 regulation of chromatin organization
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.