Search Results
Overview
| Uniprot ID | P54253 |
|---|---|
| Protein Name | Ataxin-1 |
| Gene Name | ATXN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 346 | SADLGLGKAGGKSVP |
| 712 | SVLLKHSKADGLAGS |
Function
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249). In concert with CIC and ATXN1L, involved in brain development (By similarity)
Protein Sequence
10
MKSNQERSNE
20
CLPPKKREIP
30
ATSRSSEEKA
40
PTLPSDNHRV
50
EGTAWLPGNP
60
GGRGHGGGRH
70
GPAGTSVELG
80
LQQGIGLHKA
90
LSTGLDYSPP
100
SAPRSVPVAT
110
TLPAAYATPQ
120
PGTPVSPVQY
130
AHLPHTFQFI
140
GSSQYSGTYA
150
SFIPSQLIPP
160
TANPVTSAVA
170
SAAGATTPSQ
180
RSQLEAYSTL
190
LANMGSLSQT
200
PGHKAEQQQQ
210
QQQQQQQQHQ
220
HQQQQQQQQQ
230
QQQQQHLSRA
240
PGLITPGSPP
250
PAQQNQYVHI
260
SSSPQNTGRT
270
ASPPAIPVHL
280
HPHQTMIPHT
290
LTLGPPSQVV
300
MQYADSGSHF
310
VPREATKKAE
320
SSRLQQAIQA
330
KEVLNGEMEK
340
SRRYGAPSSA
350
DLGLGKAGGK
360
SVPHPYESRH
370
VVVHPSPSDY
380
SSRDPSGVRA
390
SVMVLPNSNT
400
PAADLEVQQA
410
THREASPSTL
420
NDKSGLHLGK
430
PGHRSYALSP
440
HTVIQTTHSA
450
SEPLPVGLPA
460
TAFYAGTQPP
470
VIGYLSGQQQ
480
AITYAGSLPQ
490
HLVIPGTQPL
500
LIPVGSTDME
510
ASGAAPAIVT
520
SSPQFAAVPH
530
TFVTTALPKS
540
ENFNPEALVT
550
QAAYPAMVQA
560
QIHLPVVQSV
570
ASPAAAPPTL
580
PPYFMKGSII
590
QLANGELKKV
600
EDLKTEDFIQ
610
SAEISNDLKI
620
DSSTVERIED
630
SHSPGVAVIQ
640
FAVGEHRAQV
650
SVEVLVEYPF
660
FVFGQGWSSC
670
CPERTSQLFD
680
LPCSKLSVGD
690
VCISLTLKNL
700
KNGSVKKGQP
710
VDPASVLLKH
720
SKADGLAGSR
730
HRYAEQENGI
740
NQGSAQMLSE
750
NGELKFPEKM
760
GLPAAPFLTK
770
IEPSKPAATR
780
KRRWSAPESR
790
KLEKSEDEPP
800
LTLPKPSLIP
810
QEVKICIEGR
SNVGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0042405 | nuclear inclusion body |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0034046 | poly(G) binding |
| Molecular Function | GO:0008266 | poly(U) RNA binding |
| Molecular Function | GO:0031208 | POZ domain binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051168 | nuclear export |
| Biological Process | GO:0006396 | RNA processing |
| Biological Process | GO:0035176 | social behavior |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.