Search Results

Overview

Uniprot IDP54259
Protein NameAtrophin-1
Gene NameATN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
46 STSSSDGKAEKSRQT
840 RELERSVKLAQEGRA

Function

Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats

Protein Sequence

10 MKTRQNKDSM 20 SMRSGRKKEA 30 PGPREELRSR 40 GRASPGGVST 50 SSSDGKAEKS 60 RQTAKKARVE 70 EASTPKVNKQ 80 GRSEEISESE 90 SEETNAPKKT 100 KTEQELPRPQ 110 SPSDLDSLDG 120 RSLNDDGSSD 130 PRDIDQDNRS 140 TSPSIYSPGS 150 VENDSDSSSG 160 LSQGPARPYH 170 PPPLFPPSPQ 180 PPDSTPRQPE 190 ASFEPHPSVT 200 PTGYHAPMEP 210 PTSRMFQAPP 220 GAPPPHPQLY 230 PGGTGGVLSG 240 PPMGPKGGGA 250 ASSVGGPNGG 260 KQHPPPTTPI 270 SVSSSGASGA 280 PPTKPPTTPV 290 GGGNLPSAPP 300 PANFPHVTPN 310 LPPPPALRPL 320 NNASASPPGL 330 GAQPLPGHLP 340 SPHAMGQGMG 350 GLPPGPEKGP 360 TLAPSPHSLP 370 PASSSAPAPP 380 MRFPYSSSSS 390 SSAAASSSSS 400 SSSSSASPFP 410 ASQALPSYPH 420 SFPPPTSLSV 430 SNQPPKYTQP 440 SLPSQAVWSQ 450 GPPPPPPYGR 460 LLANSNAHPG 470 PFPPSTGAQS 480 TAHPPVSTHH 490 HHHQQQQQQQ 500 QQQQQQQQQQ 510 QQHHGNSGPP 520 PPGAFPHPLE 530 GGSSHHAHPY 540 AMSPSLGSLR 550 PYPPGPAHLP 560 PPHSQVSYSQ 570 AGPNGPPVSS 580 SSNSSSSTSQ 590 GSYPCSHPSP 600 SQGPQGAPYP 610 FPPVPTVTTS 620 SATLSTVIAT 630 VASSPAGYKT 640 ASPPGPPPYG 650 KRAPSPGAYK 660 TATPPGYKPG 670 SPPSFRTGTP 680 PGYRGTSPPA 690 GPGTFKPGSP 700 TVGPGPLPPA 710 GPSGLPSLPP 720 PPAAPASGPP 730 LSATQIKQEP 740 AEEYETPESP 750 VPPARSPSPP 760 PKVVDVPSHA 770 SQSARFNKHL 780 DRGFNSCARS 790 DLYFVPLEGS 800 KLAKKRADLV 810 EKVRREAEQR 820 AREEKERERE 830 REREKERERE 840 KERELERSVK 850 LAQEGRAPVE 860 CPSLGPVPHR 870 PPFEPGSAVA 880 TVPPYLGPDT 890 PALRTLSEYA 900 RPHVMSPGNR 910 NHPFYVPLGA 920 VDPGLLGYNV 930 PALYSSDPAA 940 REREREARER 950 DLRDRLKPGF 960 EVKPSELEPL 970 HGVPGPGLDP 980 FPRHGGLALQ 990 PGPPGLHPFP 1000 FHPSLGPLER 1010 ERLALAAGPA 1020 LRPDMSYAER 1030 LAAERQHAER 1040 VAALGNDPLA 1050 RLQMLNVTPH 1060 HHQHSHIHSH 1070 LHLHQQDAIH 1080 AASASVHPLI 1090 DPLASGSHLT 1100 RIPYPAGTLP 1110 NPLLPHPLHE 1120 NEVLRHQLFA 1130 APYRDLPASL 1140 SAPMSAAHQL 1150 QAMHAQSAEL 1160 QRLALEQQQW 1170 LHAHHPLHSV 1180 PLPAQEDYYS 1190 HLKKESDKPL

Gene Ontology

Classification GO ID Description
Biological Process GO:0030011 maintenance of cell polarity
Cellular Component GO:0070161 anchoring junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0016477 cell migration
Biological Process GO:0007417 central nervous system development
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051402 neuron apoptotic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.