Search Results
Overview
| Uniprot ID | P54274 |
|---|---|
| Protein Name | Telomeric repeat-binding factor 1 |
| Gene Name | TERF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 325 | HKNLFLSKLQHGTQQ |
| 366 | ESRIPVSKSQPVTPE |
Function
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length (PubMed:31595153). Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways
Protein Sequence
10
MAEDVSSAAP
20
SPRGCADGRD
30
ADPTEEQMAE
40
TERNDEEQFE
50
CQELLECQVQ
60
VGAPEEEEEE
70
EEDAGLVAEA
80
EAVAAGWMLD
90
FLCLSLCRAF
100
RDGRSEDFRR
110
TRNSAEAIIH
120
GLSSLTACQL
130
RTIYICQFLT
140
RIAAGKTLDA
150
QFENDERITP
160
LESALMIWGS
170
IEKEHDKLHE
180
EIQNLIKIQA
190
IAVCMENGNF
200
KEAEEVFERI
210
FGDPNSHMPF
220
KSKLLMIISQ
230
KDTFHSFFQH
240
FSYNHMMEKI
250
KSYVNYVLSE
260
KSSTFLMKAA
270
AKVVESKRTR
280
TITSQDKPSG
290
NDVEMETEAN
300
LDTRKSVSDK
310
QSAVTESSEG
320
TVSLLRSHKN
330
LFLSKLQHGT
340
QQQDLNKKER
350
RVGTPQSTKK
360
KKESRRATES
370
RIPVSKSQPV
380
TPEKHRARKR
390
QAWLWEEDKN
400
LRSGVRKYGE
410
GNWSKILLHY
420
KFNNRTSVML
430
KDRWRTMKKL
KLISSDSED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0000783 | nuclear telomere cap complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0070187 | shelterin complex |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0071532 | ankyrin repeat binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008301 | DNA binding, bending |
| Molecular Function | GO:0003691 | double-stranded telomeric DNA binding |
| Molecular Function | GO:0098505 | G-rich strand telomeric DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0042162 | telomeric DNA binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0008156 | negative regulation of DNA replication |
| Biological Process | GO:1904850 | negative regulation of establishment of protein localization to telomere |
| Biological Process | GO:1904914 | negative regulation of establishment of protein-containing complex localization to telomere |
| Biological Process | GO:1904911 | negative regulation of establishment of RNA localization to telomere |
| Biological Process | GO:0032214 | negative regulation of telomere maintenance via semi-conservative replication |
| Biological Process | GO:0032211 | negative regulation of telomere maintenance via telomerase |
| Biological Process | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| Biological Process | GO:1905839 | negative regulation of telomeric D-loop disassembly |
| Biological Process | GO:1904792 | positive regulation of shelterin complex assembly |
| Biological Process | GO:0032206 | positive regulation of telomere maintenance |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0090656 | t-circle formation |
| Biological Process | GO:0016233 | telomere capping |
| Biological Process | GO:0000723 | telomere maintenance |
| Biological Process | GO:0007004 | telomere maintenance via telomerase |
| Biological Process | GO:0061820 | telomeric D-loop disassembly |
Reference
PMID: N/A