Search Results
Overview
| Uniprot ID | P54290 |
|---|---|
| Protein Name | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
| Gene Name | Cacna2d1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 557 | IKVEIRNKMIDGESG |
| 615 | SFYYIKAKIEETITQ |
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity). Plays an important role in excitation-contraction coupling (By similarity)
Protein Sequence
10
MAAGCLLALT
20
LTLFQSWLIG
30
PSSEEPFPSP
40
VTIKSWVDKM
50
QEDLVTLAKT
60
ASGVTQLADI
70
YEKYQDLYTV
80
EPNNARQLVE
90
IAARDIEKLL
100
SNRSKALVRL
110
AMEAEKVQAA
120
HQWREDFASN
130
EVVYYNAKDD
140
LDPERNESES
150
GSQRIKPVFI
160
EDANFGRQIS
170
YQHAAVHIPT
180
DIYEGSTIVL
190
NELNWTSALD
200
EVFKRNRDED
210
PTLLWQVFAA
220
DRLARYYPAS
230
PWVDNSRTPN
240
KIDLYDVRRR
250
PWYIQGAASP
260
KDMLILVDVS
270
GSVSGLTLKL
280
IRTSVSEMLE
290
TLSDDDFVNV
300
ASFNSNAQDV
310
SCFQHLVQAN
320
VRNKKVLKDA
330
VNNITAKGIT
340
DYKKGFTFAF
350
EQLLNYNVSR
360
ANCNKIIMLF
370
TDGGEERAQE
380
IFAKYNKDKK
390
VRVFTFSVGQ
400
HNYDRGPIQW
410
MACENKGYYY
420
EIPSIGAIRI
430
NTQEYLDVLG
440
RPMVLAGDKA
450
KQVQWTNVYL
460
DALELGLVIT
470
GTLPVFNVTG
480
QSENKTNLKN
490
QLILGVMGVD
500
VSLEDIKRLT
510
PRFTLCPNGY
520
YFAIDPNGYV
530
LLHPNLQPKN
540
PKSQEPVTLD
550
FLDAELENDI
560
KVEIRNKMID
570
GESGEKTFRT
580
LVKSQDERYI
590
DKGNRTYTWT
600
PVNGTDYRYL
610
ALVLPTYSFY
620
YIKAKIEETI
630
TQARSKKGKM
640
KDSETLKPDN
650
FEESGYTFIA
660
PREYCNDLKP
670
SDNNTEFLLN
680
FNEFIDRKTP
690
NNPSCNTDLI
700
NRILLDAGFT
710
NELVQNYWSK
720
QKNIKGVKAR
730
FVVTDGGITR
740
VYPKEAGENW
750
QENPETYEDS
760
FYKRSLDNDN
770
YVFTAPYFNK
780
SGPGAYESGI
790
MVSKAVELYI
800
QGKLLKPAVV
810
GIKIDVNSWI
820
ENFTKTSIRD
830
PCAGPVCDCK
840
RNSDVMDCVI
850
LDDGGFLLMA
860
NHDDYTNQIG
870
RFFGEIDPRM
880
MRHLVNISLY
890
AFNKSYDYQS
900
VCDPGAAPKQ
910
GAGHRSAYVP
920
SITDILQIGW
930
WATAAAWSIL
940
QQLLLSLTFP
950
RLLEAVEMEE
960
DDFTASLSKQ
970
SCITEQTQYF
980
FKNDTKSFSG
990
LLDCGNCSRI
1000
FHVEKLMNTN
1010
LVFIMVESKG
1020
TCPCDTRLLM
1030
QAEQTSDGPD
1040
PCDMVKQPRY
1050
RKGPDVCFDN
1060
NVLEDYTDCG
1070
GVSGLNPSLW
1080
SIFGLQFILL
1090
WLVSGSRHYL
W
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1990454 | L-type voltage-gated calcium channel complex |
| Cellular Component | GO:0098992 | neuronal dense core vesicle |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0030315 | T-tubule |
| Cellular Component | GO:0005891 | voltage-gated calcium channel complex |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005245 | voltage-gated calcium channel activity |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0061577 | calcium ion transmembrane transport via high voltage-gated calcium channel |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0060402 | calcium ion transport into cytosol |
| Biological Process | GO:0086002 | cardiac muscle cell action potential involved in contraction |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0086048 | membrane depolarization during bundle of His cell action potential |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:1901387 | positive regulation of voltage-gated calcium channel activity |
| Biological Process | GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| Biological Process | GO:0051924 | regulation of calcium ion transport |
| Biological Process | GO:0086091 | regulation of heart rate by cardiac conduction |
| Biological Process | GO:0098903 | regulation of membrane repolarization during action potential |
| Biological Process | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.