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Overview

Uniprot IDP54311
Protein NameGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Gene NameGnb1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
15 RQEAEQLKNQIRDAR
57 TLRGHLAKIYAMHWG

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (By similarity). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)

Protein Sequence

10 MSELDQLRQE 20 AEQLKNQIRD 30 ARKACADATL 40 SQITNNIDPV 50 GRIQMRTRRT 60 LRGHLAKIYA 70 MHWGTDSRLL 80 VSASQDGKLI 90 IWDSYTTNKV 100 HAIPLRSSWV 110 MTCAYAPSGN 120 YVACGGLDNI 130 CSIYNLKTRE 140 GNVRVSRELA 150 GHTGYLSCCR 160 FLDDNQIVTS 170 SGDTTCALWD 180 IETGQQTTTF 190 TGHTGDVMSL 200 SLAPDTRLFV 210 SGACDASAKL 220 WDVREGMCRQ 230 TFTGHESDIN 240 AICFFPNGNA 250 FATGSDDATC 260 RLFDLRADQE 270 LMTYSHDNII 280 CGITSVSFSK 290 SGRLLLAGYD 300 DFNCNVWDAL 310 KADRAGVLAG 320 HDNRVSCLGV 330 TDDGMAVATG 340 SWDSFLKIWN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044297 cell body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005834 heterotrimeric G-protein complex
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0001750 photoreceptor outer segment
Cellular Component GO:0042622 photoreceptor outer segment membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0051020 GTPase binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0030159 signaling receptor complex adaptor activity
Molecular Function GO:0030507 spectrin binding
Biological Process GO:0010659 cardiac muscle cell apoptotic process
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0050909 sensory perception of taste

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.