Overview
| Uniprot ID | P54319 |
|---|
| Protein Name | Phospholipase A-2-activating protein |
|---|
| Gene Name | Plaa |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 529 |
AYRSAASKTVNIYFP |
Function
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (By similarity)
Protein Sequence
10
MASGAARYRL
20
SCSLPGHELD
30
VRGLVCCLYP
40
PGAFVSVSRD
50
RTTRLWAPDS
60
PNRGFTEMHC
70
MSGHSNFVSC
80
VCIIPSSDIY
90
PHGLIATGGN
100
DHNICIFSLD
110
SPMPLYILKG
120
HKDTVCSLSS
130
GKFGTLLSGS
140
WDTTAKVWLN
150
DKCMMTLQGH
160
TAAVWAVKIL
170
PEQGLMLTGS
180
ADKTIKLWKA
190
GRCERTFSGH
200
EDCVRGLAIL
210
SETEFLSCAN
220
DASIRRWQIT
230
GECLGVYYGH
240
TNYIYSISVF
250
PNCRDFVTTA
260
EDRSLRIWKH
270
GECAQTIRLP
280
AQSIWCCCVL
290
DNGDIVVGAS
300
DGIIRVFTEA
310
DERTASAEEI
320
KAFERELSQA
330
TIDSKTGDLG
340
DINAEQLPGR
350
EHLNEPGTRE
360
GQTRLIRDGE
370
RVEAYQWSVS
380
DGRWIKIGDV
390
VGSSGANQQT
400
SGKVLYEGKE
410
FDYVFSIDVN
420
EGGPSYKLPY
430
NVSDDPWLVA
440
YNFLQKNDLN
450
PMFLDQVAKF
460
IIDNTKGQTL
470
GLGNTSFSDP
480
FTGGGRYVPG
490
TSGPSNTVQT
500
ADPFTGAGRY
510
MPGSAGMDTT
520
MAGVDPFTGN
530
SAYRSAASKT
540
VNIYFPKKEA
550
LTFDQANPTQ
560
ILGKLKELNG
570
SAPEEKKLTE
580
DDLVLLEKIL
590
SLICGNASEK
600
PTAQQLQVLW
610
KAINWPEDIV
620
FPALDILRLS
630
IKHPSVNENF
640
CNEKEGDQFS
650
SHLINLLNPK
660
GKPANQLLAL
670
RTFCNCFVSQ
680
AGQKLMMSQR
690
ESLMSHAIEL
700
KSGSNKNIHI
710
ALATLTLNYS
720
VCFHKDHNIE
730
GKAQCLSVIS
740
TILEVVQDLE
750
ATFRLLVALG
760
TLISDDSNAI
770
QLAKSLGVDS
780
QIKKYASVSE
790
PAKVSECCRL
ILNLL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:1904949 |
ATPase complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0000153 |
cytoplasmic ubiquitin ligase complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0016005 |
phospholipase A2 activator activity |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Biological Process |
GO:0071222 |
cellular response to lipopolysaccharide |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0016236 |
macroautophagy |
| Biological Process |
GO:1900045 |
negative regulation of protein K63-linked ubiquitination |
| Biological Process |
GO:0007399 |
nervous system development |
| Biological Process |
GO:1903861 |
positive regulation of dendrite extension |
| Biological Process |
GO:2001224 |
positive regulation of neuron migration |
| Biological Process |
GO:0031394 |
positive regulation of prostaglandin biosynthetic process |
| Biological Process |
GO:1903423 |
positive regulation of synaptic vesicle recycling |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0010992 |
ubiquitin recycling |
| Biological Process |
GO:0043162 |
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.