Search Results
Overview
| Uniprot ID | P54687 |
|---|---|
| Protein Name | Branched-chain-amino-acid aminotransferase, cytosolic |
| Gene Name | BCAT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 28 | VVGTFKAKDLIVTPA |
Function
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine
Protein Sequence
10
MKDCSNGCSA
20
ECTGEGGSKE
30
VVGTFKAKDL
40
IVTPATILKE
50
KPDPNNLVFG
60
TVFTDHMLTV
70
EWSSEFGWEK
80
PHIKPLQNLS
90
LHPGSSALHY
100
AVELFEGLKA
110
FRGVDNKIRL
120
FQPNLNMDRM
130
YRSAVRATLP
140
VFDKEELLEC
150
IQQLVKLDQE
160
WVPYSTSASL
170
YIRPTFIGTE
180
PSLGVKKPTK
190
ALLFVLLSPV
200
GPYFSSGTFN
210
PVSLWANPKY
220
VRAWKGGTGD
230
CKMGGNYGSS
240
LFAQCEAVDN
250
GCQQVLWLYG
260
EDHQITEVGT
270
MNLFLYWINE
280
DGEEELATPP
290
LDGIILPGVT
300
RRCILDLAHQ
310
WGEFKVSERY
320
LTMDDLTTAL
330
EGNRVREMFG
340
SGTACVVCPV
350
SDILYKGETI
360
HIPTMENGPK
370
LASRILSKLT
380
DIQYGREESD
WTIVLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004084 | branched-chain-amino-acid transaminase activity |
| Molecular Function | GO:0052656 | L-isoleucine-2-oxoglutarate transaminase activity |
| Molecular Function | GO:0052654 | L-leucine-2-oxoglutarate transaminase activity |
| Molecular Function | GO:0052655 | L-valine-2-oxoglutarate transaminase activity |
| Biological Process | GO:0009082 | branched-chain amino acid biosynthetic process |
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0009098 | L-leucine biosynthetic process |
| Biological Process | GO:0009099 | L-valine biosynthetic process |
| Biological Process | GO:0006629 | lipid metabolic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.