Search Results
Overview
| Uniprot ID | P54819 |
|---|---|
| Protein Name | Adenylate kinase 2, mitochondrial |
| Gene Name | AK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 14 | AAEPEYPKGIRAVLL |
| 147 | TGRLIHPKSGRSYHE |
| 181 | RRSDDNEKALKIRLQ |
| 28 | LGPPGAGKGTQAPRL |
| 62 | ASGSELGKKLKATMD |
| 65 | SELGKKLKATMDAGK |
Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis
Protein Sequence
10
MAPSVPAAEP
20
EYPKGIRAVL
30
LGPPGAGKGT
40
QAPRLAENFC
50
VCHLATGDML
60
RAMVASGSEL
70
GKKLKATMDA
80
GKLVSDEMVV
90
ELIEKNLETP
100
LCKNGFLLDG
110
FPRTVRQAEM
120
LDDLMEKRKE
130
KLDSVIEFSI
140
PDSLLIRRIT
150
GRLIHPKSGR
160
SYHEEFNPPK
170
EPMKDDITGE
180
PLIRRSDDNE
190
KALKIRLQAY
200
HTQTTPLIEY
210
YRKRGIHSAI
220
DASQTPDVVF
230
ASILAAFSKA
TCKDLVMFI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0097226 | sperm mitochondrial sheath |
| Molecular Function | GO:0004017 | AMP kinase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Biological Process | GO:0006172 | ADP biosynthetic process |
| Biological Process | GO:0046033 | AMP metabolic process |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0015949 | nucleobase-containing small molecule interconversion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.