Search Results

Overview

Uniprot IDP54840
Protein NameGlycogen [starch] synthase, liver
Gene NameGYS2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
286 PNGLNVKKFSAVHEF
301 QNLHAMYKARIQDFV
381 NFNVETLKGQAVRKQ
387 LKGQAVRKQLWDVAH
397 WDVAHSVKEKFGKKL
403 VKEKFGKKLYDALLR
694 LSHVPHGKKKLHGEY
97 RAVDAMNKHGCQVHF

Function

Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan

Protein Sequence

10 MLRGRSLSVT 20 SLGGLPQWEV 30 EELPVEELLL 40 FEVAWEVTNK 50 VGGIYTVIQT 60 KAKTTADEWG 70 ENYFLIGPYF 80 EHNMKTQVEQ 90 CEPVNDAVRR 100 AVDAMNKHGC 110 QVHFGRWLIE 120 GSPYVVLFDI 130 GYSAWNLDRW 140 KGDLWEACSV 150 GIPYHDREAN 160 DMLIFGSLTA 170 WFLKEVTDHA 180 DGKYVVAQFH 190 EWQAGIGLIL 200 SRARKLPIAT 210 IFTTHATLLG 220 RYLCAANIDF 230 YNHLDKFNID 240 KEAGERQIYH 250 RYCMERASVH 260 CAHVFTTVSE 270 ITAIEAEHML 280 KRKPDVVTPN 290 GLNVKKFSAV 300 HEFQNLHAMY 310 KARIQDFVRG 320 HFYGHLDFDL 330 EKTLFLFIAG 340 RYEFSNKGAD 350 IFLESLSRLN 360 FLLRMHKSDI 370 TVMVFFIMPA 380 KTNNFNVETL 390 KGQAVRKQLW 400 DVAHSVKEKF 410 GKKLYDALLR 420 GEIPDLNDIL 430 DRDDLTIMKR 440 AIFSTQRQSL 450 PPVTTHNMID 460 DSTDPILSTI 470 RRIGLFNNRT 480 DRVKVILHPE 490 FLSSTSPLLP 500 MDYEEFVRGC 510 HLGVFPSYYE 520 PWGYTPAECT 530 VMGIPSVTTN 540 LSGFGCFMQE 550 HVADPTAYGI 560 YIVDRRFRSP 570 DDSCNQLTKF 580 LYGFCKQSRR 590 QRIIQRNRTE 600 RLSDLLDWRY 610 LGRYYQHARH 620 LTLSRAFPDK 630 FHVELTSPPT 640 TEGFKYPRPS 650 SVPPSPSGSQ 660 ASSPQSSDVE 670 DEVEDERYDE 680 EEEAERDRLN 690 IKSPFSLSHV 700 PHGKKKLHGE YKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Molecular Function GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
Molecular Function GO:0061547 glycogen synthase activity, transferring glucose-1-phosphate
Biological Process GO:0005978 glycogen biosynthetic process
Biological Process GO:0009749 response to glucose

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.