Overview
| Uniprot ID | P54851 |
|---|
| Protein Name | Epithelial membrane protein 2 |
|---|
| Gene Name | EMP2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 126 |
RREDIHDKNAKFYPV |
Function
Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell contraction through PTK2 activation (PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity). May play a role in glomerular filtration (By similarity)
Protein Sequence
10
MLVLLAFIIA
20
FHITSAALLF
30
IATVDNAWWV
40
GDEFFADVWR
50
ICTNNTNCTV
60
INDSFQEYST
70
LQAVQATMIL
80
STILCCIAFF
90
IFVLQLFRLK
100
QGERFVLTSI
110
IQLMSCLCVM
120
IAASIYTDRR
130
EDIHDKNAKF
140
YPVTREGSYG
150
YSYILAWVAF
160
ACTFISGMMY
LILRKRK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0045177 |
apical part of cell |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005178 |
integrin binding |
| Molecular Function |
GO:0019900 |
kinase binding |
| Biological Process |
GO:0007015 |
actin filament organization |
| Biological Process |
GO:0070252 |
actin-mediated cell contraction |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0032060 |
bleb assembly |
| Biological Process |
GO:0043534 |
blood vessel endothelial cell migration |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0007160 |
cell-matrix adhesion |
| Biological Process |
GO:0045022 |
early endosome to late endosome transport |
| Biological Process |
GO:0007566 |
embryo implantation |
| Biological Process |
GO:0060136 |
embryonic process involved in female pregnancy |
| Biological Process |
GO:0060914 |
heart formation |
| Biological Process |
GO:0001765 |
membrane raft assembly |
| Biological Process |
GO:0001787 |
natural killer cell proliferation |
| Biological Process |
GO:1990266 |
neutrophil migration |
| Biological Process |
GO:0044854 |
plasma membrane raft assembly |
| Biological Process |
GO:0045766 |
positive regulation of angiogenesis |
| Biological Process |
GO:0062043 |
positive regulation of cardiac epithelial to mesenchymal transition |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0001954 |
positive regulation of cell-matrix adhesion |
| Biological Process |
GO:2001046 |
positive regulation of integrin-mediated signaling pathway |
| Biological Process |
GO:0034394 |
protein localization to cell surface |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0045765 |
regulation of angiogenesis |
| Biological Process |
GO:0001952 |
regulation of cell-matrix adhesion |
| Biological Process |
GO:0010594 |
regulation of endothelial cell migration |
| Biological Process |
GO:0003093 |
regulation of glomerular filtration |
| Biological Process |
GO:0043549 |
regulation of kinase activity |
| Biological Process |
GO:2001212 |
regulation of vasculogenesis |
| Biological Process |
GO:0001913 |
T cell mediated cytotoxicity |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.