Search Results

Overview

Uniprot IDP54855
Protein NameUDP-glucuronosyltransferase 2B15
Gene NameUGT2B15
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
129 DYSNKLCKDAVLNKK
135 CKDAVLNKKLMMKLQ
232 FQIYDLKKWDQFYSE
284 FVGGLHCKPAKPLPK
287 GLHCKPAKPLPKEME
344 LWRFDGKKPNTLGSN
368 NDLLGHPKTKAFITH
410 NIAHMKAKGAALSVD
431 RDLLNALKSVINDPV
440 VINDPVYKENVMKLS
445 VYKENVMKLSRIHHD
456 IHHDQPMKPLDRAVF

Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:16595710, PubMed:18719240, PubMed:23288867, PubMed:7835232, PubMed:9295060). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:7835232). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens) (PubMed:16595710, PubMed:18719240, PubMed:23288867, PubMed:7835232, PubMed:9295060). Displays glucuronidation activity toward several classes of xenobiotic substrates, including phenolic compounds (eugenol, 4-nitrophenol, 4-hydroxybiphenyl) and phenylpropanoids (naringenin, coumarins) (PubMed:7835232). Catalyzes the glucuronidation of monoterpenoid alcohols such as borneol, menthol and isomenthol, a class of natural compounds used in essential oils (By similarity)

Protein Sequence

10 MSLKWTSVFL 20 LIQLSCYFSS 30 GSCGKVLVWP 40 TEYSHWINMK 50 TILEELVQRG 60 HEVTVLTSSA 70 STLVNASKSS 80 AIKLEVYPTS 90 LTKNYLEDSL 100 LKILDRWIYG 110 VSKNTFWSYF 120 SQLQELCWEY 130 YDYSNKLCKD 140 AVLNKKLMMK 150 LQESKFDVIL 160 ADALNPCGEL 170 LAELFNIPFL 180 YSLRFSVGYT 190 FEKNGGGFLF 200 PPSYVPVVMS 210 ELSDQMIFME 220 RIKNMIHMLY 230 FDFWFQIYDL 240 KKWDQFYSEV 250 LGRPTTLFET 260 MGKAEMWLIR 270 TYWDFEFPRP 280 FLPNVDFVGG 290 LHCKPAKPLP 300 KEMEEFVQSS 310 GENGIVVFSL 320 GSMISNMSEE 330 SANMIASALA 340 QIPQKVLWRF 350 DGKKPNTLGS 360 NTRLYKWLPQ 370 NDLLGHPKTK 380 AFITHGGTNG 390 IYEAIYHGIP 400 MVGIPLFADQ 410 HDNIAHMKAK 420 GAALSVDIRT 430 MSSRDLLNAL 440 KSVINDPVYK 450 ENVMKLSRIH 460 HDQPMKPLDR 470 AVFWIEFVMR 480 HKGAKHLRVA 490 AHNLTWIQYH 500 SLDVIAFLLA 510 CVATVIFIIT 520 KFCLFCFRKL 530 AKKGKKKKRD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0015020 glucuronosyltransferase activity
Biological Process GO:0008210 estrogen metabolic process
Biological Process GO:0008202 steroid metabolic process
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.