Search Results
Overview
| Uniprot ID | P54868 |
|---|---|
| Protein Name | Hydroxymethylglutaryl-CoA synthase, mitochondrial |
| Gene Name | HMGCS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 137 | GTETIIDKSKAVKTV |
| 221 | VAMLIGPKAPLALER |
| 243 | ENVYDFYKPNLASEY |
| 276 | CYTSYRKKIQNQWKQ |
| 282 | KKIQNQWKQAGSDRP |
| 310 | PFCKMVQKSLARLMF |
| 342 | LEAFGGLKLEDTYTN |
| 350 | LEDTYTNKDLDKALL |
| 354 | YTNKDLDKALLKASQ |
| 358 | DLDKALLKASQDMFD |
| 366 | ASQDMFDKKTKASLY |
| 437 | APGSPLDKLVSSTSD |
| 447 | SSTSDLPKRLASRKC |
| 453 | PKRLASRKCVSPEEF |
| 83 | YNNVEAGKYTVGLGQ |
Function
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate
Protein Sequence
10
MQRLLTPVKR
20
ILQLTRAVQE
30
TSLTPARLLP
40
VAHQRFSTAS
50
AVPLAKTDTW
60
PKDVGILALE
70
VYFPAQYVDQ
80
TDLEKYNNVE
90
AGKYTVGLGQ
100
TRMGFCSVQE
110
DINSLCLTVV
120
QRLMERIQLP
130
WDSVGRLEVG
140
TETIIDKSKA
150
VKTVLMELFQ
160
DSGNTDIEGI
170
DTTNACYGGT
180
ASLFNAANWM
190
ESSSWDGRYA
200
MVVCGDIAVY
210
PSGNARPTGG
220
AGAVAMLIGP
230
KAPLALERGL
240
RGTHMENVYD
250
FYKPNLASEY
260
PIVDGKLSIQ
270
CYLRALDRCY
280
TSYRKKIQNQ
290
WKQAGSDRPF
300
TLDDLQYMIF
310
HTPFCKMVQK
320
SLARLMFNDF
330
LSASSDTQTS
340
LYKGLEAFGG
350
LKLEDTYTNK
360
DLDKALLKAS
370
QDMFDKKTKA
380
SLYLSTHNGN
390
MYTSSLYGCL
400
ASLLSHHSAQ
410
ELAGSRIGAF
420
SYGSGLAASF
430
FSFRVSQDAA
440
PGSPLDKLVS
450
STSDLPKRLA
460
SRKCVSPEEF
470
TEIMNQREQF
480
YHKVNFSPPG
490
DTNSLFPGTW
500
YLERVDEQHR
RKYARRPV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006084 | acetyl-CoA metabolic process |
| Biological Process | GO:0060612 | adipose tissue development |
| Biological Process | GO:0071230 | cellular response to amino acid stimulus |
| Biological Process | GO:0071398 | cellular response to fatty acid |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0046951 | ketone body biosynthetic process |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0007494 | midgut development |
| Biological Process | GO:0033555 | multicellular organismal response to stress |
| Biological Process | GO:0051591 | response to cAMP |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0033762 | response to glucagon |
| Biological Process | GO:0060416 | response to growth hormone |
| Biological Process | GO:0070543 | response to linoleic acid |
| Biological Process | GO:0010038 | response to metal ion |
| Biological Process | GO:0034284 | response to monosaccharide |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0034696 | response to prostaglandin F |
| Biological Process | GO:0042594 | response to starvation |
| Biological Process | GO:0009266 | response to temperature stimulus |
| Biological Process | GO:0033574 | response to testosterone |
| Biological Process | GO:0034014 | response to triglyceride |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.