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Overview

Uniprot IDP54886
Protein NameDelta-1-pyrroline-5-carboxylate synthase
Gene NameALDH18A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
643 MLRVEQVKIHAGPKF

Function

Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine

Protein Sequence

10 MLSQVYRCGF 20 QPFNQHLLPW 30 VKCTTVFRSH 40 CIQPSVIRHV 50 RSWSNIPFIT 60 VPLSRTHGKS 70 FAHRSELKHA 80 KRIVVKLGSA 90 VVTRGDECGL 100 ALGRLASIVE 110 QVSVLQNQGR 120 EMMLVTSGAV 130 AFGKQRLRHE 140 ILLSQSVRQA 150 LHSGQNQLKE 160 MAIPVLEARA 170 CAAAGQSGLM 180 ALYEAMFTQY 190 SICAAQILVT 200 NLDFHDEQKR 210 RNLNGTLHEL 220 LRMNIVPIVN 230 TNDAVVPPAE 240 PNSDLQGVNV 250 ISVKDNDSLA 260 ARLAVEMKTD 270 LLIVLSDVEG 280 LFDSPPGSDD 290 AKLIDIFYPG 300 DQQSVTFGTK 310 SRVGMGGMEA 320 KVKAALWALQ 330 GGTSVVIANG 340 THPKVSGHVI 350 TDIVEGKKVG 360 TFFSEVKPAG 370 PTVEQQGEMA 380 RSGGRMLATL 390 EPEQRAEIIH 400 HLADLLTDQR 410 DEILLANKKD 420 LEEAEGRLAA 430 PLLKRLSLST 440 SKLNSLAIGL 450 RQIAASSQDS 460 VGRVLRRTRI 470 AKNLELEQVT 480 VPIGVLLVIF 490 ESRPDCLPQV 500 AALAIASGNG 510 LLLKGGKEAA 520 HSNRILHLLT 530 QEALSIHGVK 540 EAVQLVNTRE 550 EVEDLCRLDK 560 MIDLIIPRGS 570 SQLVRDIQKA 580 AKGIPVMGHS 590 EGICHMYVDS 600 EASVDKVTRL 610 VRDSKCEYPA 620 ACNALETLLI 630 HRDLLRTPLF 640 DQIIDMLRVE 650 QVKIHAGPKF 660 ASYLTFSPSE 670 VKSLRTEYGD 680 LELCIEVVDN 690 VQDAIDHIHK 700 YGSSHTDVIV 710 TEDENTAEFF 720 LQHVDSACVF 730 WNASTRFSDG 740 YRFGLGAEVG 750 ISTSRIHARG 760 PVGLEGLLTT 770 KWLLRGKDHV 780 VSDFSEHGSL 790 KYLHENLPIP QRNTN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004349 glutamate 5-kinase activity
Molecular Function GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0019240 citrulline biosynthetic process
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0055129 L-proline biosynthetic process
Biological Process GO:0006592 ornithine biosynthetic process
Biological Process GO:0009266 response to temperature stimulus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.