Search Results
Overview
| Uniprot ID | P55008 |
|---|---|
| Protein Name | Allograft inflammatory factor 1 |
| Gene Name | AIF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | TRDLQGGKAFGLLKA |
| 140 | KPTGPPAKKAISELP |
Function
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001891 | phagocytic cup |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Biological Process | GO:0051764 | actin crosslink formation |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0001774 | microglial cell activation |
| Biological Process | GO:0071672 | negative regulation of smooth muscle cell chemotaxis |
| Biological Process | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| Biological Process | GO:0030046 | parallel actin filament bundle assembly |
| Biological Process | GO:0006911 | phagocytosis, engulfment |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0032722 | positive regulation of chemokine production |
| Biological Process | GO:0050921 | positive regulation of chemotaxis |
| Biological Process | GO:0090271 | positive regulation of fibroblast growth factor production |
| Biological Process | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0090026 | positive regulation of monocyte chemotaxis |
| Biological Process | GO:0071677 | positive regulation of mononuclear cell migration |
| Biological Process | GO:0071673 | positive regulation of smooth muscle cell chemotaxis |
| Biological Process | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| Biological Process | GO:2000406 | positive regulation of T cell migration |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0016601 | Rac protein signal transduction |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0097178 | ruffle assembly |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.