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Overview

Uniprot IDP55036
Protein Name26S proteasome non-ATPase regulatory subunit 4
Gene NamePSMD4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
365 SLASQATKDGKKDKK
40 VNIVCHSKTRSNPEN
74 DTGRILSKLHTVQPK

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains

Protein Sequence

10 MVLESTMVCV 20 DNSEYMRNGD 30 FLPTRLQAQQ 40 DAVNIVCHSK 50 TRSNPENNVG 60 LITLANDCEV 70 LTTLTPDTGR 80 ILSKLHTVQP 90 KGKITFCTGI 100 RVAHLALKHR 110 QGKNHKMRII 120 AFVGSPVEDN 130 EKDLVKLAKR 140 LKKEKVNVDI 150 INFGEEEVNT 160 EKLTAFVNTL 170 NGKDGTGSHL 180 VTVPPGPSLA 190 DALISSPILA 200 GEGGAMLGLG 210 ASDFEFGVDP 220 SADPELALAL 230 RVSMEEQRQR 240 QEEEARRAAA 250 ASAAEAGIAT 260 TGTEDSDDAL 270 LKMTISQQEF 280 GRTGLPDLSS 290 MTEEEQIAYA 300 MQMSLQGAEF 310 GQAESADIDA 320 SSAMDTSEPA 330 KEEDDYDVMQ 340 DPEFLQSVLE 350 NLPGVDPNNE 360 AIRNAMGSLA 370 SQATKDGKKD KKEEDKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Cellular Component GO:0022624 proteasome accessory complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0008540 proteasome regulatory particle, base subcomplex
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0031593 polyubiquitin modification-dependent protein binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.