Search Results

Overview

Uniprot ID	P55039
Protein Name	Developmentally-regulated GTP-binding protein 2
Gene Name	DRG2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
46	AQLLEPSKSASSKGE
51	PSKSASSKGEGFDVM

Function

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation

Protein Sequence

10 MGILEKISEI 20 EKEIARTQKN 30 KATEYHLGLL 40 KAKLAKYRAQ 50 LLEPSKSASS 60 KGEGFDVMKS 70 GDARVALIGF 80 PSVGKSTFLS 90 LMTSTASEAA 100 SYEFTTLTCI 110 PGVIEYKGAN 120 IQLLDLPGII 130 EGAAQGKGRG 140 RQVIAVARTA 150 DVIIMMLDAT 160 KGEVQRSLLE 170 KELESVGIRL 180 NKHKPNIYFK 190 PKKGGGISFN 200 STVTLTQCSE 210 KLVQLILHEY 220 KIFNAEVLFR 230 EDCSPDEFID 240 VIVGNRVYMP 250 CLYVYNKIDQ 260 ISMEEVDRLA 270 RKPNSVVISC 280 GMKLNLDYLL 290 EMLWEYLALT 300 CIYTKKRGQR 310 PDFTDAIILR 320 KGASVEHVCH 330 RIHRSLASQF 340 KYALVWGTST 350 KYSPQRVGLT 360 HTMEHEDVIQ IVKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0002181	cytoplasmic translation
Biological Process	GO:0007165	signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.