Overview
| Uniprot ID | P55053 |
|---|
| Protein Name | Fatty acid-binding protein 5 |
|---|
| Gene Name | Fabp5 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 103 |
QHQKWEGKESTITRK |
| 34 |
GVGLALRKMGAMAKP |
| 61 |
VKTESTVKTTVFSCT |
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity)
Protein Sequence
10
MASLKDLEGK
20
WRLVESHGFE
30
DYMKELGVGL
40
ALRKMGAMAK
50
PDCIITLDGN
60
NLTVKTESTV
70
KTTVFSCTLG
80
EKFDETTADG
90
RKTETVCTFT
100
DGALVQHQKW
110
EGKESTITRK
120
LKDGKMVVEC
130
VMNNAICTRV
YEKVQ
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0015908 |
fatty acid transport |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0099524 |
postsynaptic cytosol |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0099092 |
postsynaptic density, intracellular component |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0005504 |
fatty acid binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005324 |
long-chain fatty acid transmembrane transporter activity |
| Molecular Function |
GO:0001972 |
retinoic acid binding |
| Biological Process |
GO:0042593 |
glucose homeostasis |
| Biological Process |
GO:0006006 |
glucose metabolic process |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:1990379 |
lipid transport across blood-brain barrier |
| Biological Process |
GO:0015909 |
long-chain fatty acid transport |
| Biological Process |
GO:0010829 |
negative regulation of D-glucose transmembrane transport |
| Biological Process |
GO:0006656 |
phosphatidylcholine biosynthetic process |
| Biological Process |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
| Biological Process |
GO:0035360 |
positive regulation of peroxisome proliferator activated receptor signaling pathway |
| Biological Process |
GO:0031392 |
regulation of prostaglandin biosynthetic process |
| Biological Process |
GO:0099178 |
regulation of retrograde trans-synaptic signaling by endocanabinoid |
| Biological Process |
GO:0051930 |
regulation of sensory perception of pain |
| Biological Process |
GO:0098921 |
retrograde trans-synaptic signaling by endocannabinoid |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.