Search Results

Overview

Uniprot IDP55081
Protein NameMicrofibrillar-associated protein 1
Gene NameMFAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
242 ERRKYTLKIVEEETK
26 AVPVRNEKGEISMEK
329 NGKVITNKAVKGKYK
340 GKYKFLQKYYHRGAF
376 FNKTILPKVMQVKNF
381 LPKVMQVKNFGRSGR
415 QESAQNTKFFKQKAA

Function

Involved in pre-mRNA splicing as a component of the spliceosome

Protein Sequence

10 MSVPSALMKQ 20 PPIQSTAGAV 30 PVRNEKGEIS 40 MEKVKVKRYV 50 SGKRPDYAPM 60 ESSDEEDEEF 70 QFIKKAKEQE 80 AEPEEQEEDS 90 SSDPRLRRLQ 100 NRISEDVEER 110 LARHRKIVEP 120 EVVGESDSEV 130 EGDAWRMERE 140 DSSEEEEEEI 150 DDEEIERRRG 160 MMRQRAQERK 170 NEEMEVMEVE 180 DEGRSGEESE 190 SESEYEEYTD 200 SEDEMEPRLK 210 PVFIRKKDRV 220 TVQEREAEAL 230 KQKELEQEAK 240 RMAEERRKYT 250 LKIVEEETKK 260 ELEENKRSLA 270 ALDALNTDDE 280 NDEEEYEAWK 290 VRELKRIKRD 300 REDREALEKE 310 KAEIERMRNL 320 TEEERRAELR 330 ANGKVITNKA 340 VKGKYKFLQK 350 YYHRGAFFMD 360 EDEEVYKRDF 370 SAPTLEDHFN 380 KTILPKVMQV 390 KNFGRSGRTK 400 YTHLVDQDTT 410 SFDSAWGQES 420 AQNTKFFKQK 430 AAGVRDVFER PSAKKRKTT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001527 microfibril
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Cellular Component GO:0005684 U2-type spliceosomal complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.