Overview
| Uniprot ID | P55087 |
|---|
| Protein Name | Aquaporin-4 |
|---|
| Gene Name | AQP4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 268 |
RFKEAFSKAAQQTKG |
| 274 |
SKAAQQTKGSYMEVE |
| 295 |
ETDDLILKPGVVHVI |
| 310 |
DVDRGEEKKGKDQSG |
| 313 |
RGEEKKGKDQSGEVL |
Function
Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity)
Protein Sequence
10
MSDRPTARRW
20
GKCGPLCTRE
30
NIMVAFKGVW
40
TQAFWKAVTA
50
EFLAMLIFVL
60
LSLGSTINWG
70
GTEKPLPVDM
80
VLISLCFGLS
90
IATMVQCFGH
100
ISGGHINPAV
110
TVAMVCTRKI
120
SIAKSVFYIA
130
AQCLGAIIGA
140
GILYLVTPPS
150
VVGGLGVTMV
160
HGNLTAGHGL
170
LVELIITFQL
180
VFTIFASCDS
190
KRTDVTGSIA
200
LAIGFSVAIG
210
HLFAINYTGA
220
SMNPARSFGP
230
AVIMGNWENH
240
WIYWVGPIIG
250
AVLAGGLYEY
260
VFCPDVEFKR
270
RFKEAFSKAA
280
QQTKGSYMEV
290
EDNRSQVETD
300
DLILKPGVVH
310
VIDVDRGEEK
320
KGKDQSGEVL
SSV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0097450 |
astrocyte end-foot |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0015250 |
water channel activity |
| Biological Process |
GO:0071346 |
cellular response to type II interferon |
| Biological Process |
GO:0090660 |
cerebrospinal fluid circulation |
| Biological Process |
GO:0009992 |
intracellular water homeostasis |
| Biological Process |
GO:0050891 |
multicellular organismal-level water homeostasis |
| Biological Process |
GO:0051289 |
protein homotetramerization |
| Biological Process |
GO:0003091 |
renal water homeostasis |
| Biological Process |
GO:0006833 |
water transport |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.