Search Results

Overview

Uniprot IDP55157
Protein NameMicrosomal triglyceride transfer protein large subunit
Gene NameMTTP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
131 LLHLIHGKVKEFYSY
133 HLIHGKVKEFYSYQN
149 AVAIENIKRGLASLF
184 TYQAHQDKVIKIKAL
189 QDKVIKIKALDSCKI
195 IKALDSCKIARSGFT
271 GPRLMSGKQAAAIIK
278 KQAAAIIKAVDSKYT
313 ELWRSTRKYLQPDNL
322 LQPDNLSKAEAVRNF
340 IQHLRTAKKEEILQI
341 QHLRTAKKEEILQIL
416 RALISKFKGSIGSSD
448 QNEGCKLKAVVEAKK
454 LKAVVEAKKLILGGL
455 KAVVEAKKLILGGLE
463 LILGGLEKAEKKEDT
50 LLDRGKGKLQDSVGY
598 KIVRRVLKEMVAHNY
798 TVDSSFVKAGLETST
857 GRGYVSQKRKESVLA

Function

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:16478722, PubMed:23475612, PubMed:26224785, PubMed:8876250, PubMed:8939939). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity)

Protein Sequence

10 MILLAVLFLC 20 FISSYSASVK 30 GHTTGLSLNN 40 DRLYKLTYST 50 EVLLDRGKGK 60 LQDSVGYRIS 70 SNVDVALLWR 80 NPDGDDDQLI 90 QITMKDVNVE 100 NVNQQRGEKS 110 IFKGKSPSKI 120 MGKENLEALQ 130 RPTLLHLIHG 140 KVKEFYSYQN 150 EAVAIENIKR 160 GLASLFQTQL 170 SSGTTNEVDI 180 SGNCKVTYQA 190 HQDKVIKIKA 200 LDSCKIARSG 210 FTTPNQVLGV 220 SSKATSVTTY 230 KIEDSFVIAV 240 LAEETHNFGL 250 NFLQTIKGKI 260 VSKQKLELKT 270 TEAGPRLMSG 280 KQAAAIIKAV 290 DSKYTAIPIV 300 GQVFQSHCKG 310 CPSLSELWRS 320 TRKYLQPDNL 330 SKAEAVRNFL 340 AFIQHLRTAK 350 KEEILQILKM 360 ENKEVLPQLV 370 DAVTSAQTSD 380 SLEAILDFLD 390 FKSDSSIILQ 400 ERFLYACGFA 410 SHPNEELLRA 420 LISKFKGSIG 430 SSDIRETVMI 440 ITGTLVRKLC 450 QNEGCKLKAV 460 VEAKKLILGG 470 LEKAEKKEDT 480 RMYLLALKNA 490 LLPEGIPSLL 500 KYAEAGEGPI 510 SHLATTALQR 520 YDLPFITDEV 530 KKTLNRIYHQ 540 NRKVHEKTVR 550 TAAAAIILNN 560 NPSYMDVKNI 570 LLSIGELPQE 580 MNKYMLAIVQ 590 DILRFEMPAS 600 KIVRRVLKEM 610 VAHNYDRFSR 620 SGSSSAYTGY 630 IERSPRSAST 640 YSLDILYSGS 650 GILRRSNLNI 660 FQYIGKAGLH 670 GSQVVIEAQG 680 LEALIAATPD 690 EGEENLDSYA 700 GMSAILFDVQ 710 LRPVTFFNGY 720 SDLMSKMLSA 730 SGDPISVVKG 740 LILLIDHSQE 750 LQLQSGLKAN 760 IEVQGGLAID 770 ISGAMEFSLW 780 YRESKTRVKN 790 RVTVVITTDI 800 TVDSSFVKAG 810 LETSTETEAG 820 LEFISTVQFS 830 QYPFLVCMQM 840 DKDEAPFRQF 850 EKKYERLSTG 860 RGYVSQKRKE 870 SVLAGCEFPL 880 HQENSEMCKV 890 VFAPQPDSTS SGWF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0031526 brush border membrane
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0031528 microvillus membrane
Cellular Component GO:0043235 receptor complex
Cellular Component GO:0031982 vesicle
Molecular Function GO:0034185 apolipoprotein binding
Molecular Function GO:1902388 ceramide 1-phosphate transfer activity
Molecular Function GO:0120020 cholesterol transfer activity
Molecular Function GO:0008289 lipid binding
Molecular Function GO:0005319 lipid transporter activity
Molecular Function GO:0120019 phosphatidylcholine transfer activity
Molecular Function GO:1904121 phosphatidylethanolamine transfer activity
Molecular Function GO:0120014 phospholipid transfer activity
Molecular Function GO:0005548 phospholipid transporter activity
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0140344 triglyceride transfer activity
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0034378 chylomicron assembly
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0042157 lipoprotein metabolic process
Biological Process GO:0015914 phospholipid transport
Biological Process GO:0034377 plasma lipoprotein particle assembly
Biological Process GO:0009306 protein secretion
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0034197 triglyceride transport
Biological Process GO:0034379 very-low-density lipoprotein particle assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.