Search Results
Overview
| Uniprot ID | P55161 |
|---|---|
| Protein Name | Nck-associated protein 1 |
| Gene Name | Nckap1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 394 | RHADNMPKKSADDFI |
| 395 | HADNMPKKSADDFID |
| 421 | ELRAHVRKYGPVMQR |
| 44 | ACGDPKAKPSYLIDK |
| 643 | TISQAVNKKSKKQTG |
Function
Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)
Protein Sequence
10
MSRSVLQPSQ
20
QKLAEKLTIL
30
NDRGVGMLTR
40
LYNIKKACGD
50
PKAKPSYLID
60
KNLESAVKFI
70
VRKFPAVETR
80
NNNQQLAQLQ
90
KEKSEILKNL
100
ALYYFTFVDV
110
MEFKDHVCDL
120
LNTIDVCQVF
130
FDITVNFDLT
140
KNYLDLTVTY
150
TTLMILLSRI
160
EERKAIIGLY
170
NYAHEMTHGA
180
SDREYPRLGQ
190
MIVDYEHPLK
200
KMMEEFVPHS
210
KSLSDALISL
220
QMVYPRRNLS
230
ADQWRNAQLL
240
SLISAPSTML
250
NPAQSDTMPC
260
EYLSLDAMEK
270
WIIFGFILCH
280
GMLNTEATAL
290
NLWKLALQSS
300
SCLSLFRDEV
310
FHIHKAAEDL
320
FVNIRGYNKR
330
INDIRECKEA
340
AVSHAGSMHR
350
ERRKFLRSAL
360
KELATVLSDQ
370
PGLLGPKALF
380
VFMALSFARD
390
EIIWLLRHAD
400
NMPKKSADDF
410
IDKHIAELIF
420
YMEELRAHVR
430
KYGPVMQRYY
440
VQYLSGFDAV
450
VLNELVQNLS
460
VCPEDESIIM
470
SSFVNTMTSL
480
SVKQVEDGEV
490
FDFRGMRLDW
500
FRLQAYTSVS
510
KASLSLADHR
520
ELGKMMNTII
530
FHTKMVDSLV
540
EMLVETSDLS
550
IFCFYSRAFE
560
KMFQQCLELP
570
SQSRYSIAFP
580
LLCTHFMSCT
590
HELCPEERHH
600
IGDRSLSLCN
610
MFLDEMAKQA
620
RNLITDICTE
630
QCTLSDQLLP
640
KHCAKTISQA
650
VNKKSKKQTG
660
KKGEPEREKP
670
GVESMRKNRL
680
VVTNLDKLHT
690
ALSELCFSIN
700
YVPNMAVWEH
710
TFTPREYLTS
720
HLEIRFTKSI
730
VGMTMYNQAT
740
QEIAKPSELL
750
TSVREYMTVL
760
QSIENYVQID
770
ITRVFNNVLL
780
QQTQHLDSHG
790
EPTITSLYTN
800
WYLETLLRQV
810
SNGHIAYFPA
820
MKAFVNLPTE
830
NELTFNAEEY
840
SDISEMRSLS
850
ELLGPYGMKF
860
LSESLMWHIS
870
SQVAELKKLV
880
VENVDVLTQM
890
RTSFDKPDQM
900
AALFKRLSSV
910
DSVLKRMTII
920
GVILSFRSLA
930
QEALRDVLSY
940
HIPFLVSSIE
950
DFKDHIPRET
960
DMKVAMNVYE
970
LSSAAGLPCE
980
IDPALVVALS
990
SQKSENISPE
1000
EEYKIACLLM
1010
VFVAVSLPTL
1020
ASNVMSQYSP
1030
AIEGHCNNIH
1040
CLAKAINQIA
1050
AALFTIHKGS
1060
IEDRLKEFLA
1070
LASSSLLKIG
1080
QETDKTTTRN
1090
RESVYLLLDM
1100
IVQESPFLTM
1110
DLLESCFPYV
1120
LLRNAYHAVY
KQSVTSSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0031258 | lamellipodium membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0031209 | SCAR complex |
| Biological Process | GO:0045176 | apical protein localization |
| Biological Process | GO:0045175 | basal protein localization |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0042074 | cell migration involved in gastrulation |
| Biological Process | GO:0000902 | cell morphogenesis |
| Biological Process | GO:0030031 | cell projection assembly |
| Biological Process | GO:0030866 | cortical actin cytoskeleton organization |
| Biological Process | GO:0010172 | embryonic body morphogenesis |
| Biological Process | GO:0048617 | embryonic foregut morphogenesis |
| Biological Process | GO:0035050 | embryonic heart tube development |
| Biological Process | GO:0007492 | endoderm development |
| Biological Process | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0030032 | lamellipodium assembly |
| Biological Process | GO:0008078 | mesodermal cell migration |
| Biological Process | GO:0001843 | neural tube closure |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0030903 | notochord development |
| Biological Process | GO:0048570 | notochord morphogenesis |
| Biological Process | GO:0048339 | paraxial mesoderm development |
| Biological Process | GO:0048340 | paraxial mesoderm morphogenesis |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0016601 | Rac protein signal transduction |
| Biological Process | GO:0032880 | regulation of protein localization |
| Biological Process | GO:0001756 | somitogenesis |
| Biological Process | GO:0007354 | zygotic determination of anterior/posterior axis, embryo |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.