Search Results

Overview

Uniprot ID	P55197
Protein Name	Protein AF-10
Gene Name	MLLT10
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
451	SLPTAGYKRAQTSGI

Function

Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302)

Protein Sequence

10 MVSSDRPVSL 20 EDEVSHSMKE 30 MIGGCCVCSD 40 ERGWAENPLV 50 YCDGHGCSVA 60 VHQACYGIVQ 70 VPTGPWFCRK 80 CESQERAARV 90 RCELCPHKDG 100 ALKRTDNGGW 110 AHVVCALYIP 120 EVQFANVSTM 130 EPIVLQSVPH 140 DRYNKTCYIC 150 DEQGRESKAA 160 TGACMTCNKH 170 GCRQAFHVTC 180 AQFAGLLCEE 190 EGNGADNVQY 200 CGYCKYHFSK 210 LKKSKRGSNR 220 SYDQSLSDSS 230 SHSQDKHHEK 240 EKKKYKEKDK 250 HKQKHKKQPE 260 PSPALVPSLT 270 VTTEKTYTST 280 SNNSISGSLK 290 RLEDTTARFT 300 NANFQEVSAH 310 TSSGKDVSET 320 RGSEGKGKKS 330 SAHSSGQRGR 340 KPGGGRNPGT 350 TVSAASPFPQ 360 GSFSGTPGSV 370 KSSSGSSVQS 380 PQDFLSFTDS 390 DLRNDSYSHS 400 QQSSATKDVH 410 KGESGSQEGG 420 VNSFSTLIGL 430 PSTSAVTSQP 440 KSFENSPGDL 450 GNSSLPTAGY 460 KRAQTSGIEE 470 ETVKEKKRKG 480 NKQSKHGPGR 490 PKGNKNQENV 500 SHLSVSSASP 510 TSSVASAAGS 520 ITSSSLQKSP 530 TLLRNGSLQS 540 LSVGSSPVGS 550 EISMQYRHDG 560 ACPTTTFSEL 570 LNAIHNGIYN 580 SNDVAVSFPN 590 VVSGSGSSTP 600 VSSSHLPQQS 610 SGHLQQVGAL 620 SPSAVSSAAP 630 AVATTQANTL 640 SGSSLSQAPS 650 HMYGNRSNSS 660 MAALIAQSEN 670 NQTDQDLGDN 680 SRNLVGRGSS 690 PRGSLSPRSP 700 VSSLQIRYDQ 710 PGNSSLENLP 720 PVAASIEQLL 730 ERQWSEGQQF 740 LLEQGTPSDI 750 LGMLKSLHQL 760 QVENRRLEEQ 770 IKNLTAKKER 780 LQLLNAQLSV 790 PFPTITANPS 800 PSHQIHTFSA 810 QTAPTTDSLN 820 SSKSPHIGNS 830 FLPDNSLPVL 840 NQDLTSSGQS 850 TSSSSALSTP 860 PPAGQSPAQQ 870 GSGVSGVQQV 880 NGVTVGALAS 890 GMQPVTSTIP 900 AVSAVGGIIG 910 ALPGNQLAIN 920 GIVGALNGVM 930 QTPVTMSQNP 940 TPLTHTTVPP 950 NATHPMPATL 960 TNSASGLGLL 970 SDQQRQILIH 980 QQQFQQLLNS 990 QQLTPEQHQA 1000 FLYQLMQHHH 1010 QQHHQPELQQ 1020 LQIPGPTQIP 1030 INNLLAGTQA 1040 PPLHTATTNP 1050 FLTIHGDNAS 1060 QKVARLSDKT GPVAQEKS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0140566	histone reader activity
Molecular Function	GO:0031491	nucleosome binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

PMID: N/A