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Overview

Uniprot ID	P55199
Protein Name	RNA polymerase II elongation factor ELL
Gene Name	ELL
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
129	ATDDSYQKARQSMAQ
150	SRSAIVIKAGGRYLG
164	GKKVQFRKPAPGATD
190	NLASAIRKSGASAVS
355	AQPAVNGKLGVPNGR

Function

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation

Protein Sequence

10 MAALKEDRSY 20 GLSCGRVSDG 30 SKVSVFHVKL 40 TDSALRAFES 50 YRARQDSVSL 60 RPSIRFQGSQ 70 GHISIPQPDC 80 PAEARTFSFY 90 LSNIGRDNPQ 100 GSFDCIQQYV 110 SSHGEVHLDC 120 LGSIQDKITV 130 CATDDSYQKA 140 RQSMAQAEEE 150 TRSRSAIVIK 160 AGGRYLGKKV 170 QFRKPAPGAT 180 DAVPSRKRAT 190 PINLASAIRK 200 SGASAVSGGS 210 GVSQRPFRDR 220 VLHLLALRPY 230 RKAELLLRLQ 240 KDGLTQADKD 250 ALDGLLQQVA 260 NMSAKDGTCT 270 LQDCMYKDVQ 280 KDWPGYSEGD 290 QQLLKRVLVR 300 KLCQPQSTGS 310 LLGDPAASSP 320 PGERGRSASP 330 PQKRLQPPDF 340 IDPLANKKPR 350 ISHFTQRAQP 360 AVNGKLGVPN 370 GREALLPTPG 380 PPASTDTLSS 390 STHLPPRLEP 400 PRAHDPLADV 410 SNDLGHSGRD 420 CEHGEAAAPA 430 PTVRLGLPLL 440 TDCAQPSRPH 450 GSPSRSKPKK 460 KSKKHKDKER 470 AAEDKPRAQL 480 PDCAPATHAT 490 PGAPADTPGL 500 NGTCSVSSVP 510 TSTSETPDYL 520 LKYAAISSSE 530 QRQSYKNDFN 540 AEYSEYRDLH 550 ARIERITRRF 560 TQLDAQLRQL 570 SQGSEEYETT 580 RGQILQEYRK 590 IKKTNTNYSQ 600 EKHRCEYLHS 610 KLAHIKRLIA 620 EYDQRQLQAW P

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015030	Cajal body
Cellular Component	GO:0000791	euchromatin
Cellular Component	GO:0035363	histone locus body
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0008023	transcription elongation factor complex
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0019902	phosphatase binding
Biological Process	GO:0032786	positive regulation of DNA-templated transcription, elongation
Biological Process	GO:1905382	positive regulation of snRNA transcription by RNA polymerase II
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III
Biological Process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II
Biological Process	GO:0042795	snRNA transcription by RNA polymerase II
Biological Process	GO:0042796	snRNA transcription by RNA polymerase III
Biological Process	GO:0006368	transcription elongation by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.