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Overview

Uniprot IDP55201
Protein NamePeregrin
Gene NameBRPF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
800 LDEVNASKQSVGRSR
896 RTSVLFSKKNPKTAG
897 TSVLFSKKNPKTAGP
983 GGNQPVKKSFLVYRN

Function

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:24065767, PubMed:27939640). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:24065767). Some HAT complexes preferentially mediate histone H3 'Lys-23' (H3K23ac) acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358)

Protein Sequence

10 MGVDFDVKTF 20 CHNLRATKPP 30 YECPVETCRK 40 VYKSYSGIEY 50 HLYHYDHDNP 60 PPPQQTPLRK 70 HKKKGRQSRP 80 ANKQSPSPSE 90 VSQSPGREVM 100 SYAQAQRMVE 110 VDLHGRVHRI 120 SIFDNLDVVS 130 EDEEAPEEAP 140 ENGSNKENTE 150 TPAATPKSGK 160 HKNKEKRKDS 170 NHHHHHNVSA 180 STTPKLPEVV 190 YRELEQDTPD 200 APPRPTSYYR 210 YIEKSAEELD 220 EEVEYDMDEE 230 DYIWLDIMNE 240 RRKTEGVSPI 250 PQEIFEYLMD 260 RLEKESYFES 270 HNKGDPNALV 280 DEDAVCCICN 290 DGECQNSNVI 300 LFCDMCNLAV 310 HQECYGVPYI 320 PEGQWLCRRC 330 LQSPSRAVDC 340 ALCPNKGGAF 350 KQTDDGRWAH 360 VVCALWIPEV 370 CFANTVFLEP 380 IDSIEHIPPA 390 RWKLTCYICK 400 QRGSGACIQC 410 HKANCYTAFH 420 VTCAQQAGLY 430 MKMEPVRETG 440 ANGTSFSVRK 450 TAYCDIHTPP 460 GSARRLPALS 470 HSEGEEDEDE 480 EEDEGKGWSS 490 EKVKKAKAKS 500 RIKMKKARKI 510 LAEKRAAAPV 520 VSVPCIPPHR 530 LSKITNRLTI 540 QRKSQFMQRL 550 HSYWTLKRQS 560 RNGVPLLRRL 570 QTHLQSQRNC 580 DQVGRDSEDK 590 NWALKEQLKS 600 WQRLRHDLER 610 ARLLVELIRK 620 REKLKRETIK 630 VQQIAMEMQL 640 TPFLILLRKT 650 LEQLQEKDTG 660 NIFSEPVPLS 670 EVPDYLDHIK 680 KPMDFFTMKQ 690 NLEAYRYLNF 700 DDFEEDFNLI 710 VSNCLKYNAK 720 DTIFYRAAVR 730 LREQGGAVLR 740 QARRQAEKMG 750 IDFETGMHIP 760 HSLAGDEATH 770 HTEDAAEEER 780 LVLLENQKHL 790 PVEEQLKLLL 800 ERLDEVNASK 810 QSVGRSRRAK 820 MIKKEMTALR 830 RKLAHQRETG 840 RDGPERHGPS 850 SRGSLTPHPA 860 ACDKDGQTDS 870 AAEESSSQET 880 SKGLGPNMSS 890 TPAHEVGRRT 900 SVLFSKKNPK 910 TAGPPKRPGR 920 PPKNRESQMT 930 PSHGGSPVGP 940 PQLPIMSSLR 950 QRKRGRSPRP 960 SSSSDSDSDK 970 STEDPPMDLP 980 ANGFSGGNQP 990 VKKSFLVYRN 1000 DCSLPRSSSD 1010 SESSSSSSSS 1020 AASDRTSTTP 1030 SKQGRGKPSF 1040 SRGTFPEDSS 1050 EDTSGTENEA 1060 YSVGTGRGVG 1070 HSMVRKSLGR 1080 GAGWLSEDED 1090 SPLDALDLVW 1100 AKCRGYPSYP 1110 ALIIDPKMPR 1120 EGMFHHGVPI 1130 PVPPLEVLKL 1140 GEQMTQEARE 1150 HLYLVLFFDN 1160 KRTWQWLPRT 1170 KLVPLGVNQD 1180 LDKEKMLEGR 1190 KSNIRKSVQI 1200 AYHRALQHRS 1210 KVQGEQSSET SDSD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000123 histone acetyltransferase complex
Cellular Component GO:0070776 MOZ/MORF histone acetyltransferase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0010698 acetyltransferase activator activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0140566 histone reader activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0050793 regulation of developmental process
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:1903706 regulation of hemopoiesis
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.