Search Results

Overview

Uniprot IDP55209
Protein NameNucleosome assembly protein 1-like 1
Gene NameNAP1L1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 EVHDLERKYAVLYQP
116 LYQPLFDKRFEIINA
266 QIDWKKGKNVTLKTI
271 KGKNVTLKTIKKKQK
82 KRRVNALKNLQVKCA
87 ALKNLQVKCAQIEAK

Function

Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly (PubMed:20002496, PubMed:21211722, PubMed:26841755). Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair (PubMed:28369616). Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (PubMed:24798879). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity)

Protein Sequence

10 MADIDNKEQS 20 ELDQDLDDVE 30 EVEEEETGEE 40 TKLKARQLTV 50 QMMQNPQILA 60 ALQERLDGLV 70 ETPTGYIESL 80 PRVVKRRVNA 90 LKNLQVKCAQ 100 IEAKFYEEVH 110 DLERKYAVLY 120 QPLFDKRFEI 130 INAIYEPTEE 140 ECEWKPDEED 150 EISEELKEKA 160 KIEDEKKDEE 170 KEDPKGIPEF 180 WLTVFKNVDL 190 LSDMVQEHDE 200 PILKHLKDIK 210 VKFSDAGQPM 220 SFVLEFHFEP 230 NEYFTNEVLT 240 KTYRMRSEPD 250 DSDPFSFDGP 260 EIMGCTGCQI 270 DWKKGKNVTL 280 KTIKKKQKHK 290 GRGTVRTVTK 300 TVSNDSFFNF 310 FAPPEVPESG 320 DLDDDAEAIL 330 AADFEIGHFL 340 RERIIPRSVL 350 YFTGEAIEDD 360 DDDYDEEGEE 370 ADEEGEEEGD 380 EENDPDYDPK 390 KDQNPAECKQ Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Biological Process GO:0007399 nervous system development
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:2000179 positive regulation of neural precursor cell proliferation
Biological Process GO:0050769 positive regulation of neurogenesis
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140713 histone chaperone activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006260 DNA replication

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.