Overview
| Uniprot ID | P55264 |
|---|
| Protein Name | Adenosine kinase |
|---|
| Gene Name | Adk |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 10 |
AADEPKPKKLKVEAP |
Function
Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines (PubMed:15317590, PubMed:6407470). Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification (PubMed:40840445). Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction (PubMed:40840445). Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL (PubMed:40840445)
Protein Sequence
10
MAAADEPKPK
20
KLKVEAPQAL
30
SENVLFGMGN
40
PLLDISAVVD
50
KDFLDKYSLK
60
PNDQILAEDK
70
HKELFDELVK
80
KFKVEYHAGG
90
STQNSMKVAQ
100
WLIQEPHKAA
110
TFFGCIGIDK
120
FGEILKRKAA
130
DAHVDAHYYE
140
QNEQPTGTCA
150
ACITGGNRSL
160
VANLAAANCY
170
KKEKHLDLER
180
NWVLVEKARV
190
YYIAGFFLTV
200
SPESVLKVAR
210
YAAENNRVFT
220
LNLSAPFISQ
230
FFKEALMDVM
240
PYVDILFGNE
250
TEAATFAREQ
260
GFETKDIKEI
270
AKKAQALPKV
280
NSKRQRTVIF
290
TQGRDDTIVA
300
AENDVTAFPV
310
LDQNQEEIID
320
TNGAGDAFVG
330
GFLSQLVSDK
340
PLTECIRAGH
350
YAASVIIRRT
360
GCTFPEKPDF
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0004001 |
adenosine kinase activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004136 |
deoxyadenosine kinase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0046085 |
adenosine metabolic process |
| Biological Process |
GO:0044209 |
AMP salvage |
| Biological Process |
GO:0006175 |
dATP biosynthetic process |
| Biological Process |
GO:0010613 |
positive regulation of cardiac muscle hypertrophy |
| Biological Process |
GO:0042102 |
positive regulation of T cell proliferation |
| Biological Process |
GO:0006144 |
purine nucleobase metabolic process |
| Biological Process |
GO:0032261 |
purine nucleotide salvage |
| Biological Process |
GO:0006166 |
purine ribonucleoside salvage |
| Biological Process |
GO:0110052 |
toxic metabolite repair |
| Biological Process |
GO:0044342 |
type B pancreatic cell proliferation |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.