Search Results
Overview
| Uniprot ID | P55268 |
|---|---|
| Protein Name | Laminin subunit beta-2 |
| Gene Name | LAMB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1603 | WAEDEKQKAETVQAA |
| 1720 | VKALAERKAQGVLAA |
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
Protein Sequence
10
MELTSRERGR
20
GQPLPWELRL
30
GLLLSVLAAT
40
LAQAPAPDVP
50
GCSRGSCYPA
60
TGDLLVGRAD
70
RLTASSTCGL
80
NGPQPYCIVS
90
HLQDEKKCFL
100
CDSRRPFSAR
110
DNPHSHRIQN
120
VVTSFAPQRR
130
AAWWQSENGI
140
PAVTIQLDLE
150
AEFHFTHLIM
160
TFKTFRPAAM
170
LVERSADFGR
180
TWHVYRYFSY
190
DCGADFPGVP
200
LAPPRHWDDV
210
VCESRYSEIE
220
PSTEGEVIYR
230
VLDPAIPIPD
240
PYSSRIQNLL
250
KITNLRVNLT
260
RLHTLGDNLL
270
DPRREIREKY
280
YYALYELVVR
290
GNCFCYGHAS
300
ECAPAPGAPA
310
HAEGMVHGAC
320
ICKHNTRGLN
330
CEQCQDFYRD
340
LPWRPAEDGH
350
SHACRKCECH
360
GHTHSCHFDM
370
AVYLASGNVS
380
GGVCDGCQHN
390
TAGRHCELCR
400
PFFYRDPTKD
410
LRDPAVCRSC
420
DCDPMGSQDG
430
GRCDSHDDPA
440
LGLVSGQCRC
450
KEHVVGTRCQ
460
QCRDGFFGLS
470
ISDRLGCRRC
480
QCNARGTVPG
490
STPCDPNSGS
500
CYCKRLVTGR
510
GCDRCLPGHW
520
GLSHDLLGCR
530
PCDCDVGGAL
540
DPQCDEGTGQ
550
CHCRQHMVGR
560
RCEQVQPGYF
570
RPFLDHLIWE
580
AEDTRGQVLD
590
VVERLVTPGE
600
TPSWTGSGFV
610
RLQEGQTLEF
620
LVASVPKAMD
630
YDLLLRLEPQ
640
VPEQWAELEL
650
IVQRPGPVPA
660
HSLCGHLVPK
670
DDRIQGTLQP
680
HARYLIFPNP
690
VCLEPGISYK
700
LHLKLVRTGG
710
SAQPETPYSG
720
PGLLIDSLVL
730
LPRVLVLEMF
740
SGGDAAALER
750
QATFERYQCH
760
EEGLVPSKTS
770
PSEACAPLLI
780
SLSTLIYNGA
790
LPCQCNPQGS
800
LSSECNPHGG
810
QCLCKPGVVG
820
RRCDLCAPGY
830
YGFGPTGCQA
840
CQCSHEGALS
850
SLCEKTSGQC
860
LCRTGAFGLR
870
CDRCQRGQWG
880
FPSCRPCVCN
890
GHADECNTHT
900
GACLGCRDHT
910
GGEHCERCIA
920
GFHGDPRLPY
930
GGQCRPCPCP
940
EGPGSQRHFA
950
TSCHQDEYSQ
960
QIVCHCRAGY
970
TGLRCEACAP
980
GHFGDPSRPG
990
GRCQLCECSG
1000
NIDPMDPDAC
1010
DPHTGQCLRC
1020
LHHTEGPHCA
1030
HCKPGFHGQA
1040
ARQSCHRCTC
1050
NLLGTNPQQC
1060
PSPDQCHCDP
1070
SSGQCPCLPN
1080
VQGPSCDRCA
1090
PNFWNLTSGH
1100
GCQPCACHPS
1110
RARGPTCNEF
1120
TGQCHCRAGF
1130
GGRTCSECQE
1140
LHWGDPGLQC
1150
HACDCDSRGI
1160
DTPQCHRFTG
1170
HCSCRPGVSG
1180
VRCDQCARGF
1190
SGIFPACHPC
1200
HACFGDWDRV
1210
VQDLAARTQR
1220
LEQRAQELQQ
1230
TGVLGAFESS
1240
FWHMQEKLGI
1250
VQGIVGARNT
1260
SAASTAQLVE
1270
ATEELRREIG
1280
EATEHLTQLE
1290
ADLTDVQDEN
1300
FNANHALSGL
1310
ERDRLALNLT
1320
LRQLDQHLDL
1330
LKHSNFLGAY
1340
DSIRHAHSQS
1350
AEAERRANTS
1360
ALAVPSPVSN
1370
SASARHRTEA
1380
LMDAQKEDFN
1390
SKHMANQRAL
1400
GKLSAHTHTL
1410
SLTDINELVC
1420
GAPGDAPCAT
1430
SPCGGAGCRD
1440
EDGQPRCGGL
1450
SCNGAAATAD
1460
LALGRARHTQ
1470
AELQRALAEG
1480
GSILSRVAET
1490
RRQASEAQQR
1500
AQAALDKANA
1510
SRGQVEQANQ
1520
ELQELIQSVK
1530
DFLNQEGADP
1540
DSIEMVATRV
1550
LELSIPASAE
1560
QIQHLAGAIA
1570
ERVRSLADVD
1580
AILARTVGDV
1590
RRAEQLLQDA
1600
RRARSWAEDE
1610
KQKAETVQAA
1620
LEEAQRAQGI
1630
AQGAIRGAVA
1640
DTRDTEQTLY
1650
QVQERMAGAE
1660
RALSSAGERA
1670
RQLDALLEAL
1680
KLKRAGNSLA
1690
ASTAEETAGS
1700
AQGRAQEAEQ
1710
LLRGPLGDQY
1720
QTVKALAERK
1730
AQGVLAAQAR
1740
AEQLRDEARD
1750
LLQAAQDKLQ
1760
RLQELEGTYE
1770
ENERALESKA
1780
AQLDGLEARM
1790
RSVLQAINLQ
VQIYNTCQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005608 | laminin-121 trimer |
| Cellular Component | GO:0005609 | laminin-221 trimer |
| Cellular Component | GO:0005612 | laminin-321 trimer |
| Cellular Component | GO:0043258 | laminin-421 trimer |
| Cellular Component | GO:1990338 | laminin-423 trimer |
| Cellular Component | GO:0043260 | laminin-521 trimer |
| Cellular Component | GO:1990339 | laminin-522 trimer |
| Cellular Component | GO:1990340 | laminin-523 trimer |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0043083 | synaptic cleft |
| Molecular Function | GO:0005201 | extracellular matrix structural constituent |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0150043 | structural constituent of synapse-associated extracellular matrix |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0045785 | positive regulation of cell adhesion |
| Biological Process | GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| Biological Process | GO:0051149 | positive regulation of muscle cell differentiation |
| Biological Process | GO:0110011 | regulation of basement membrane organization |
| Biological Process | GO:0034446 | substrate adhesion-dependent cell spreading |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.