Search Results

Overview

Uniprot IDP55327
Protein NameTumor protein D52
Gene NameTPD52
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 LSQVLAAKEKHLAEI
102 QVLAAKEKHLAEIKR
108 EKHLAEIKRKLGINS
110 HLAEIKRKLGINSLQ
125 ELKQNIAKGWQDVTA
137 VTATSAYKKTSETLS
138 TATSAYKKTSETLSQ
149 TLSQAGQKASAAFSS
163 SVGSVITKKLEDVKN
164 VGSVITKKLEDVKNS
169 TKKLEDVKNSPTFKS
175 VKNSPTFKSFEEKVE
185 EEKVENLKSKVGGTK
187 KVENLKSKVGGTKPA

Function

No function data available.

Protein Sequence

10 MDCREMDLYE 20 DYQSPFDFDA 30 GVNKSYLYLS 40 PSGNSSPPGS 50 PTLQKFGLLR 60 TDPVPEEGED 70 VAATISATET 80 LSEEEQEELR 90 RELAKVEEEI 100 QTLSQVLAAK 110 EKHLAEIKRK 120 LGINSLQELK 130 QNIAKGWQDV 140 TATSAYKKTS 150 ETLSQAGQKA 160 SAAFSSVGSV 170 ITKKLEDVKN 180 SPTFKSFEEK 190 VENLKSKVGG 200 TKPAGGDFGE 210 VLNSAANASA 220 TTTEPLPEKT QESL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0046903 secretion

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.