Search Results
Overview
| Uniprot ID | P55769 |
|---|---|
| Protein Name | NHP2-like protein 1 |
| Gene Name | SNU13 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | ADAHLTKKLLDLVQQ |
| 33 | VQQSCNYKQLRKGAN |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:10545122, PubMed:17412961, PubMed:28781166). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0000244 | spliceosomal tri-snRNP complex assembly |
| Cellular Component | GO:0031428 | box C/D methylation guide snoRNP complex |
| Cellular Component | GO:0001651 | dense fibrillar component |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0071011 | precatalytic spliceosome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0032040 | small-subunit processome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Cellular Component | GO:0046540 | U4/U6 x U5 tri-snRNP complex |
| Cellular Component | GO:0005690 | U4atac snRNP |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0034512 | box C/D sno(s)RNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0034511 | U3 snoRNA binding |
| Molecular Function | GO:0030621 | U4 snRNA binding |
| Molecular Function | GO:0030622 | U4atac snRNA binding |
| Biological Process | GO:0000492 | box C/D snoRNP assembly |
| Biological Process | GO:0030490 | maturation of SSU-rRNA |
| Biological Process | GO:0016556 | mRNA modification |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0042274 | ribosomal small subunit biogenesis |
| Biological Process | GO:0000451 | rRNA 2'-O-methylation |
| Biological Process | GO:0000245 | spliceosomal complex assembly |
| Biological Process | GO:0000387 | spliceosomal snRNP assembly |
| Biological Process | GO:0000388 | spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.