Overview
| Uniprot ID | P55770 |
|---|
| Protein Name | NHP2-like protein 1 |
|---|
| Gene Name | Snu13 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
LADAHLTKKLLDLVQ |
| 21 |
ADAHLTKKLLDLVQQ |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (By similarity)
Protein Sequence
10
MTEADVNPKA
20
YPLADAHLTK
30
KLLDLVQQSC
40
NYKQLRKGAN
50
EATKTLNRGI
60
SEFIVMAADA
70
EPLEIILHLP
80
LLCEDKNVPY
90
VFVRSKQALG
100
RACGVSRPVI
110
ACSVTIKEGS
120
QLKQQIQSIQ
QSIERLLV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031428 |
box C/D methylation guide snoRNP complex |
| Cellular Component |
GO:0001651 |
dense fibrillar component |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0071011 |
precatalytic spliceosome |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Cellular Component |
GO:0005681 |
spliceosomal complex |
| Cellular Component |
GO:0071016 |
U12-type precatalytic spliceosome |
| Cellular Component |
GO:0071005 |
U2-type precatalytic spliceosome |
| Cellular Component |
GO:0046540 |
U4/U6 x U5 tri-snRNP complex |
| Cellular Component |
GO:0005690 |
U4atac snRNP |
| Molecular Function |
GO:0051117 |
ATPase binding |
| Molecular Function |
GO:0034512 |
box C/D sno(s)RNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0034511 |
U3 snoRNA binding |
| Molecular Function |
GO:0030621 |
U4 snRNA binding |
| Molecular Function |
GO:0030622 |
U4atac snRNA binding |
| Biological Process |
GO:0000492 |
box C/D snoRNP assembly |
| Biological Process |
GO:0030490 |
maturation of SSU-rRNA |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
| Biological Process |
GO:0007338 |
single fertilization |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.