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Overview

Uniprot IDP56181
Protein NameNADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Gene NameNDUFV3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
57 KKQSPPKKPAPVPAE

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I

Protein Sequence

10 MAAPCLLRQG 20 RAGALKTMLQ 30 EAQVFRGLAS 40 TVSLSAESGK 50 SEKGQPQNSK 60 KQSPPKKPAP 70 VPAEPFDNTT 80 YKNLQHHDYS 90 TYTFLDLNLE 100 LSKFRMPQPS SGRESPRH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045271 respiratory chain complex I
Molecular Function GO:0008137 NADH dehydrogenase (ubiquinone) activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0009060 aerobic respiration
Biological Process GO:0042775 mitochondrial ATP synthesis coupled electron transport
Biological Process GO:0006120 mitochondrial electron transport, NADH to ubiquinone
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.