Search Results
Overview
| Uniprot ID | P56199 |
|---|---|
| Protein Name | Integrin alpha-1 |
| Gene Name | ITGA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 238 | EEVLVAAKKIVQRGG |
| 274 | GARRGVKKVMVIVTD |
| 292 | HDNHRLKKVIQDCED |
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth
Protein Sequence
10
MAPRPRARPG
20
VAVACCWLLT
30
VVLRCCVSFN
40
VDVKNSMTFS
50
GPVEDMFGYT
60
VQQYENEEGK
70
WVLIGSPLVG
80
QPKNRTGDVY
90
KCPVGRGESL
100
PCVKLDLPVN
110
TSIPNVTEVK
120
ENMTFGSTLV
130
TNPNGGFLAC
140
GPLYAYRCGH
150
LHYTTGICSD
160
VSPTFQVVNS
170
IAPVQECSTQ
180
LDIVIVLDGS
190
NSIYPWDSVT
200
AFLNDLLERM
210
DIGPKQTQVG
220
IVQYGENVTH
230
EFNLNKYSST
240
EEVLVAAKKI
250
VQRGGRQTMT
260
ALGIDTARKE
270
AFTEARGARR
280
GVKKVMVIVT
290
DGESHDNHRL
300
KKVIQDCEDE
310
NIQRFSIAIL
320
GSYNRGNLST
330
EKFVEEIKSI
340
ASEPTEKHFF
350
NVSDELALVT
360
IVKTLGERIF
370
ALEATADQSA
380
ASFEMEMSQT
390
GFSAHYSQDW
400
VMLGAVGAYD
410
WNGTVVMQKA
420
SQIIIPRNTT
430
FNVESTKKNE
440
PLASYLGYTV
450
NSATASSGDV
460
LYIAGQPRYN
470
HTGQVIIYRM
480
EDGNIKILQT
490
LSGEQIGSYF
500
GSILTTTDID
510
KDSNTDILLV
520
GAPMYMGTEK
530
EEQGKVYVYA
540
LNQTRFEYQM
550
SLEPIKQTCC
560
SSRQHNSCTT
570
ENKNEPCGAR
580
FGTAIAAVKD
590
LNLDGFNDIV
600
IGAPLEDDHG
610
GAVYIYHGSG
620
KTIRKEYAQR
630
IPSGGDGKTL
640
KFFGQSIHGE
650
MDLNGDGLTD
660
VTIGGLGGAA
670
LFWSRDVAVV
680
KVTMNFEPNK
690
VNIQKKNCHM
700
EGKETVCINA
710
TVCFDVKLKS
720
KEDTIYEADL
730
QYRVTLDSLR
740
QISRSFFSGT
750
QERKVQRNIT
760
VRKSECTKHS
770
FYMLDKHDFQ
780
DSVRITLDFN
790
LTDPENGPVL
800
DDSLPNSVHE
810
YIPFAKDCGN
820
KEKCISDLSL
830
HVATTEKDLL
840
IVRSQNDKFN
850
VSLTVKNTKD
860
SAYNTRTIVH
870
YSPNLVFSGI
880
EAIQKDSCES
890
NHNITCKVGY
900
PFLRRGEMVT
910
FKILFQFNTS
920
YLMENVTIYL
930
SATSDSEEPP
940
ETLSDNVVNI
950
SIPVKYEVGL
960
QFYSSASEYH
970
ISIAANETVP
980
EVINSTEDIG
990
NEINIFYLIR
1000
KSGSFPMPEL
1010
KLSISFPNMT
1020
SNGYPVLYPT
1030
GLSSSENANC
1040
RPHIFEDPFS
1050
INSGKKMTTS
1060
TDHLKRGTIL
1070
DCNTCKFATI
1080
TCNLTSSDIS
1090
QVNVSLILWK
1100
PTFIKSYFSS
1110
LNLTIRGELR
1120
SENASLVLSS
1130
SNQKRELAIQ
1140
ISKDGLPGRV
1150
PLWVILLSAF
1160
AGLLLLMLLI
1170
LALWKIGFFK
RPLKKKMEK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0045178 | basal part of cell |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0034665 | integrin alpha1-beta1 complex |
| Cellular Component | GO:0008305 | integrin complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005518 | collagen binding |
| Molecular Function | GO:0098639 | collagen binding involved in cell-matrix adhesion |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0019211 | phosphatase activator activity |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0060326 | cell chemotaxis |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:0042311 | vasodilation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.