Search Results

Overview

Uniprot IDP56211
Protein NamecAMP-regulated phosphoprotein 19
Gene NameARPP19
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
109 KPSLVASKLAG****
33 KAEEAKLKARYPHLG
58 KRLQKGQKYFDSGDY
69 SGDYNMAKAKMKNKQ
71 DYNMAKAKMKNKQLP
75 AKAKMKNKQLPTAAP

Function

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) (PubMed:28167675, PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:28167675, PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity)

Protein Sequence

10 MSAEVPEAAS 20 AEEQKEMEDK 30 VTSPEKAEEA 40 KLKARYPHLG 50 QKPGGSDFLR 60 KRLQKGQKYF 70 DSGDYNMAKA 80 KMKNKQLPTA 90 APDKTEVTGD 100 HIPTPQDLPQ 110 RKPSLVASKL AG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0019212 phosphatase inhibitor activity
Molecular Function GO:0015459 potassium channel regulator activity
Molecular Function GO:0051721 protein phosphatase 2A binding
Molecular Function GO:0004864 protein phosphatase inhibitor activity
Molecular Function GO:0019888 protein phosphatase regulator activity
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0051301 cell division
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:0045722 positive regulation of gluconeogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.