Search Results
Overview
| Uniprot ID | P56392 |
|---|---|
| Protein Name | Cytochrome c oxidase subunit 7A1, mitochondrial |
| Gene Name | Cox7a1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 31 | NRVAEKQKLFQADND |
Function
Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:22119795, PubMed:22869013). The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity (By similarity). Despite being highly expressed in brown adipose tissue, not required for thermogenesis (PubMed:26635001)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0098803 | respiratory chain complex |
| Cellular Component | GO:0045277 | respiratory chain complex IV |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen |
| Biological Process | GO:0097250 | mitochondrial respirasome assembly |
| Biological Process | GO:0006119 | oxidative phosphorylation |
| Biological Process | GO:1902600 | proton transmembrane transport |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.