Overview
| Uniprot ID | P56432 |
|---|
| Protein Name | Transcription factor Jun |
|---|
| Gene Name | JUN |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 268 |
RNRIAASKCRKRKLE |
| 309 |
REQVAQLKQKVMNHV |
Function
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity). Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity). Interacts with FOSB to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 site of FASLG/CD95L, and activating its transcription in T cells upon stimulation by TCR/CD3 (By similarity)
Protein Sequence
10
MTAKMETTFY
20
DDALNASFLQ
30
SESGAYGYSN
40
PKILKQSMTL
50
NLADPVGNLK
60
PHLRAQDSDL
70
LTSPDVGLLK
80
LASPELERLI
90
IQSSNGHITT
100
TPTPTQFLCP
110
KNVTDEQEGF
120
AEGFVRALAE
130
LHSQNTLPSV
140
TSAAQPVSGA
150
GLVAPAVASV
160
AGGSGSGGFS
170
ASLHSEPPVY
180
ANLSNFNPGA
190
LSSGGGAPSY
200
GAAGLAFPAQ
210
PQQQQQQPPQ
220
PPHHLPVQHP
230
RLQALKEEPQ
240
TVPEMPGETP
250
PLSPIDMESQ
260
ERIKAERKRM
270
RNRIAASKCR
280
KRKLERIARL
290
EEKVKTLKAQ
300
NSELASTANM
310
LREQVAQLKQ
320
KVMNHVNSGC
330
QLMLTQQLQT
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005667 |
transcription regulator complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0000976 |
transcription cis-regulatory region binding |
| Biological Process |
GO:0071222 |
cellular response to lipopolysaccharide |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006955 |
immune response |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0042127 |
regulation of cell population proliferation |
| Biological Process |
GO:0048545 |
response to steroid hormone |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.