Search Results

Overview

Uniprot IDP56470
Protein NameGalectin-4
Gene NameLGALS4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
261 GSWGSEEKKITHNPF
262 SWGSEEKKITHNPFG
286 RCGLDRFKVYANGQH
73 PRFDGWDKVVFNTLQ
83 FNTLQGGKWGSEERK

Function

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions

Protein Sequence

10 MAYVPAPGYQ 20 PTYNPTLPYY 30 QPIPGGLNVG 40 MSVYIQGVAS 50 EHMKRFFVNF 60 VVGQDPGSDV 70 AFHFNPRFDG 80 WDKVVFNTLQ 90 GGKWGSEERK 100 RSMPFKKGAA 110 FELVFIVLAE 120 HYKVVVNGNP 130 FYEYGHRLPL 140 QMVTHLQVDG 150 DLQLQSINFI 160 GGQPLRPQGP 170 PMMPPYPGPG 180 HCHQQLNSLP 190 TMEGPPTFNP 200 PVPYFGRLQG 210 GLTARRTIII 220 KGYVPPTGKS 230 FAINFKVGSS 240 GDIALHINPR 250 MGNGTVVRNS 260 LLNGSWGSEE 270 KKITHNPFGP 280 GQFFDLSIRC 290 GLDRFKVYAN 300 GQHLFDFAHR 310 LSAFQRVDTL 320 EIQGDVTLSY VQI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0016936 galactoside binding
Biological Process GO:0007155 cell adhesion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.