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Overview

Uniprot ID	P56480
Protein Name	ATP synthase F(1) complex catalytic subunit beta, mitochondrial
Gene Name	Atp5f1b
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
124	EGLVRGQKVLDSGAP
133	LDSGAPIKIPVGPET
198	DLLAPYAKGGKIGLF
201	APYAKGGKIGLFGGA
426	DVARGVQKILQDYKS
485	MGKLVPLKETIKGFQ
522	EAVAKADKLAEEHGS

Function

Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (Probable) (PubMed:21281446). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (By similarity)

Protein Sequence

10 MLSLVGRVAS 20 ASASGALRGL 30 SPSAALPQAQ 40 LLLRAAPAGV 50 HPARDYAAQA 60 SAAPKAGTAT 70 GRIVAVIGAV 80 VDVQFDEGLP 90 PILNALEVQG 100 RDSRLVLEVA 110 QHLGESTVRT 120 IAMDGTEGLV 130 RGQKVLDSGA 140 PIKIPVGPET 150 LGRIMNVIGE 160 PIDERGPIKT 170 KQFAPIHAEA 180 PEFIEMSVEQ 190 EILVTGIKVV 200 DLLAPYAKGG 210 KIGLFGGAGV 220 GKTVLIMELI 230 NNVAKAHGGY 240 SVFAGVGERT 250 REGNDLYHEM 260 IESGVINLKD 270 ATSKVALVYG 280 QMNEPPGARA 290 RVALTGLTVA 300 EYFRDQEGQD 310 VLLFIDNIFR 320 FTQAGSEVSA 330 LLGRIPSAVG 340 YQPTLATDMG 350 TMQERITTTK 360 KGSITSVQAI 370 YVPADDLTDP 380 APATTFAHLD 390 ATTVLSRAIA 400 ELGIYPAVDP 410 LDSTSRIMDP 420 NIVGNEHYDV 430 ARGVQKILQD 440 YKSLQDIIAI 450 LGMDELSEED 460 KLTVSRARKI 470 QRFLSQPFQV 480 AEVFTGHMGK 490 LVPLKETIKG 500 FQQILAGEYD 510 HLPEQAFYMV 520 GPIEEAVAKA DKLAEEHGS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0042645	mitochondrial nucleoid
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0043209	myelin sheath
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045259	proton-transporting ATP synthase complex
Molecular Function	GO:0043531	ADP binding
Molecular Function	GO:0043532	angiostatin binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0030228	lipoprotein particle receptor activity
Molecular Function	GO:0042288	MHC class I protein binding
Molecular Function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
Molecular Function	GO:0046961	proton-transporting ATPase activity, rotational mechanism
Biological Process	GO:0001525	angiogenesis
Biological Process	GO:0006754	ATP biosynthetic process
Biological Process	GO:0098761	cellular response to interleukin-7
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration
Biological Process	GO:0015986	proton motive force-driven ATP synthesis
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis
Biological Process	GO:1902600	proton transmembrane transport
Biological Process	GO:0006898	receptor-mediated endocytosis
Biological Process	GO:0051453	regulation of intracellular pH

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.