Search Results

Overview

Uniprot IDP56545
Protein NameC-terminal-binding protein 2
Gene NameCTBP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
6 **MALVDKHKVKRQR

Function

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity)

Protein Sequence

10 MALVDKHKVK 20 RQRLDRICEG 30 IRPQIMNGPL 40 HPRPLVALLD 50 GRDCTVEMPI 60 LKDLATVAFC 70 DAQSTQEIHE 80 KVLNEAVGAM 90 MYHTITLTRE 100 DLEKFKALRV 110 IVRIGSGYDN 120 VDIKAAGELG 130 IAVCNIPSAA 140 VEETADSTIC 150 HILNLYRRNT 160 WLYQALREGT 170 RVQSVEQIRE 180 VASGAARIRG 190 ETLGLIGFGR 200 TGQAVAVRAK 210 AFGFSVIFYD 220 PYLQDGIERS 230 LGVQRVYTLQ 240 DLLYQSDCVS 250 LHCNLNEHNH 260 HLINDFTIKQ 270 MRQGAFLVNA 280 ARGGLVDEKA 290 LAQALKEGRI 300 RGAALDVHES 310 EPFSFAQGPL 320 KDAPNLICTP 330 HTAWYSEQAS 340 LEMREAAATE 350 IRRAITGRIP 360 ESLRNCVNKE 370 FFVTSAPWSV 380 IDQQAIHPEL 390 NGATYRYPPG 400 IVGVAPGGLP 410 AAMEGIIPGG 420 IPVTHNLPTV 430 AHPSQAPSPN 440 QPTKHGDNRE HPNEQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0045202 synapse
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0001221 transcription coregulator binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0001222 transcription corepressor binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0048386 positive regulation of retinoic acid receptor signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0019079 viral genome replication
Biological Process GO:0050872 white fat cell differentiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.