Search Results

Overview

Uniprot IDP56574
Protein NameIsocitrate dehydrogenase [NADP], mitochondrial
Gene NameIdh2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
133 FKLKKMWKSPNGTIR
155 FREPIICKNIPRLVP
180 HAHGDQYKATDFVVD
199 FKLVFTPKDGSGAKE
256 STKNTIMKAYDGRFK
272 IFQEIFDKHYKTDFD
275 EIFDKHYKTDFDKNK
280 HYKTDFDKNKIWYEH
282 KTDFDKNKIWYEHRL
384 RGLEHRGKLDGNQDL
413 VESGAMTKDLAGCIH
48 EKRIKVEKPVVEMDG
69 IWQFIKEKLILPHVD

Function

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex

Protein Sequence

10 MAGYLRAVSS 20 LCRASGSTRT 30 WAPAALNVPS 40 WPEQPRRHYA 50 EKRIKVEKPV 60 VEMDGDEMTR 70 IIWQFIKEKL 80 ILPHVDVQLK 90 YFDLGLPNRD 100 QTNDQVTIDS 110 ALATQKYSVA 120 VKCATITPDE 130 ARVEEFKLKK 140 MWKSPNGTIR 150 NILGGTVFRE 160 PIICKNIPRL 170 VPGWTKPITI 180 GRHAHGDQYK 190 ATDFVVDRAG 200 MFKLVFTPKD 210 GSGAKEWEVY 220 NFPAGGVGMG 230 MYNTDESISG 240 FAHSCFQYSI 250 QKKWPLYLST 260 KNTIMKAYDG 270 RFKDIFQEIF 280 DKHYKTDFDK 290 NKIWYEHRLI 300 DDMVAQVLKS 310 SGGFVWACKN 320 YDGDVQSDIL 330 AQGFGSLGLM 340 TSVLVCPDGK 350 TIEAEAAHGT 360 VTRHYREHQK 370 GRPTSTNPIA 380 SIFAWTRGLE 390 HRGKLDGNQD 400 LIRFAQTLEK 410 VCVQTVESGA 420 MTKDLAGCIH 430 GLSNVKLNEH 440 FLNTTDFLDT 450 IKSNLDRALG KQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0004450 isocitrate dehydrogenase (NADP+) activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0006097 glyoxylate cycle
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0006741 NADP+ biosynthetic process
Biological Process GO:0006739 NADP+ metabolic process
Biological Process GO:1903976 negative regulation of glial cell migration
Biological Process GO:0060253 negative regulation of glial cell proliferation
Biological Process GO:1904465 negative regulation of matrix metallopeptidase secretion
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.