Search Results
Overview
| Uniprot ID | P56945 |
|---|---|
| Protein Name | Breast cancer anti-estrogen resistance protein 1 |
| Gene Name | BCAR1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 335 | DVPPAFAKAKPFDPA |
| 337 | PPAFAKAKPFDPART |
Function
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity)
Protein Sequence
10
MNHLNVLAKA
20
LYDNVAESPD
30
ELSFRKGDIM
40
TVLEQDTQGL
50
DGWWLCSLHG
60
RQGIVPGNRL
70
KILVGMYDKK
80
PAGPGPGPPA
90
TPAQPQPGLH
100
APAPPASQYT
110
PMLPNTYQPQ
120
PDSVYLVPTP
130
SKAQQGLYQV
140
PGPSPQFQSP
150
PAKQTSTFSK
160
QTPHHPFPSP
170
ATDLYQVPPG
180
PGGPAQDIYQ
190
VPPSAGMGHD
200
IYQVPPSMDT
210
RSWEGTKPPA
220
KVVVPTRVGQ
230
GYVYEAAQPE
240
QDEYDIPRHL
250
LAPGPQDIYD
260
VPPVRGLLPS
270
QYGQEVYDTP
280
PMAVKGPNGR
290
DPLLEVYDVP
300
PSVEKGLPPS
310
NHHAVYDVPP
320
SVSKDVPDGP
330
LLREETYDVP
340
PAFAKAKPFD
350
PARTPLVLAA
360
PPPDSPPAED
370
VYDVPPPAPD
380
LYDVPPGLRR
390
PGPGTLYDVP
400
RERVLPPEVA
410
DGGVVDSGVY
420
AVPPPAEREA
430
PAEGKRLSAS
440
STGSTRSSQS
450
ASSLEVAGPG
460
REPLELEVAV
470
EALARLQQGV
480
SATVAHLLDL
490
AGSAGATGSW
500
RSPSEPQEPL
510
VQDLQAAVAA
520
VQSAVHELLE
530
FARSAVGNAA
540
HTSDRALHAK
550
LSRQLQKMED
560
VHQTLVAHGQ
570
ALDAGRGGSG
580
ATLEDLDRLV
590
ACSRAVPEDA
600
KQLASFLHGN
610
ASLLFRRTKA
620
TAPGPEGGGT
630
LHPNPTDKTS
640
SIQSRPLPSP
650
PKFTSQDSPD
660
GQYENSEGGW
670
MEDYDYVHLQ
680
GKEEFEKTQK
690
ELLEKGSITR
700
QGKSQLELQQ
710
LKQFERLEQE
720
VSRPIDHDLA
730
NWTPAQPLAP
740
GRTGGLGPSD
750
RQLLLFYLEQ
760
CEANLTTLTN
770
AVDAFFTAVA
780
TNQPPKIFVA
790
HSKFVILSAH
800
KLVFIGDTLS
810
RQAKAADVRS
820
QVTHYSNLLC
830
DLLRGIVATT
840
KAAALQYPSP
850
SAAQDMVERV
860
KELGHSTQQF
870
RRVLGQLAAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0050851 | antigen receptor-mediated signaling pathway |
| Biological Process | GO:0050853 | B cell receptor signaling pathway |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0060326 | cell chemotaxis |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway |
| Biological Process | GO:0035729 | cellular response to hepatocyte growth factor stimulus |
| Biological Process | GO:0086100 | endothelin receptor signaling pathway |
| Biological Process | GO:0007173 | epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0048012 | hepatocyte growth factor receptor signaling pathway |
| Biological Process | GO:0008286 | insulin receptor signaling pathway |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| Biological Process | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0001558 | regulation of cell growth |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
| Biological Process | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.