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Overview

Uniprot IDP57678
Protein NameGem-associated protein 4
Gene NameGEMIN4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
201 DEFPHPPKRLRSDPD

Function

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP

Protein Sequence

10 MDLGPLNICE 20 EMTILHGGFL 30 LAEQLFHPKA 40 LAELTKSDWE 50 RVGRPIVEAL 60 REISSAAAHS 70 QPFAWKKKAL 80 IIIWAKVLQP 90 HPVTPSDTET 100 RWQEDLFFSV 110 GNMIPTINHT 120 ILFELLKSLE 130 ASGLFIQLLM 140 ALPTTICHAE 150 LERFLEHVTV 160 DTSAEDVAFF 170 LDVWWEVMKH 180 KGHPQDPLLS 190 QFSAMAHKYL 200 PALDEFPHPP 210 KRLRSDPDAC 220 PTMPLLAMLL 230 RGLTQIQSRI 240 LGPGRKCCAL 250 ANLADMLTVF 260 ALTEDDPQEV 270 SATVYLDKLA 280 TVISVWNSDT 290 QNPYHQQALA 300 EKVKEAERDV 310 SLTSLAKLPS 320 ETIFVGCEFL 330 HHLLREWGEE 340 LQAVLRSSQG 350 TSYDSYRLCD 360 SLTSFSQNAT 370 LYLNRTSLSK 380 EDRQVVSELA 390 ECVRDFLRKT 400 STVLKNRALE 410 DITASIAMAV 420 IQQKMDRHME 430 VCYIFASEKK 440 WAFSDEWVAC 450 LGSNRALFRQ 460 PDLVLRLLET 470 VIDVSTADRA 480 IPESQIRQVI 490 HLILECYADL 500 SLPGKNKVLA 510 GILRSWGRKG 520 LSEKLLAYVE 530 GFQEDLNTTF 540 NQLTQSASEQ 550 GLAKAVASVA 560 RLVIVHPEVT 570 VKKMCSLAVV 580 NLGTHKFLAQ 590 ILTAFPALRF 600 VEEQGPNSSA 610 TFMVSCLKET 620 VWMKFSTPKE 630 EKQFLELLNC 640 LMSPVKPQGI 650 PVAALLEPDE 660 VLKEFVLPFL 670 RLDVEEVDLS 680 LRIFIQTLEA 690 NACREEYWLQ 700 TCSPFPLLFS 710 LCQLLDRFSK 720 YWQLPKEKRC 730 LSLDRKDLAI 740 HILELLCEIV 750 SANAETFSPD 760 VWIKSLSWLH 770 RKLEQLDWTV 780 GLRLKSFFEG 790 HFKCEVPATL 800 FEICKLSEDE 810 WTSQAHPGYG 820 AGTGLLAWME 830 CCCVSSGISE 840 RMLSLLVVDV 850 GNPEEVRLFS 860 KGFLVALVQV 870 MPWCSPQEWQ 880 RLHQLTRRLL 890 EKQLLHVPYS 900 LEYIQFVPLL 910 NLKPFAQELQ 920 LSVLFLRTFQ 930 FLCSHSCRDW 940 LPLEGWNHVV 950 KLLCGSLTRL 960 LDSVRAIQAA 970 GPWVQGPEQD 980 LTQEALFVYT 990 QVFCHALHIM 1000 AMLHPEVCEP 1010 LYVLALETLT 1020 CYETLSKTNP 1030 SVSSLLQRAH 1040 EQRFLKSIAE 1050 GIGPEERRQT LLQKMSSF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0097504 Gemini of Cajal bodies
Cellular Component GO:0016020 membrane
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0030532 small nuclear ribonucleoprotein complex
Cellular Component GO:0032797 SMN complex
Cellular Component GO:0034719 SMN-Sm protein complex
Molecular Function GO:0043021 ribonucleoprotein complex binding
Biological Process GO:0006364 rRNA processing
Biological Process GO:0000387 spliceosomal snRNP assembly

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.