Search Results
Overview
| Uniprot ID | P57723 |
|---|---|
| Protein Name | Poly(rC)-binding protein 4 |
| Gene Name | PCBP4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 35 | EVGSIIGKKGETVKR |
| 36 | VGSIIGKKGETVKRI |
Function
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC
Protein Sequence
10
MSGSDGGLEE
20
EPELSITLTL
30
RMLMHGKEVG
40
SIIGKKGETV
50
KRIREQSSAR
60
ITISEGSCPE
70
RITTITGSTA
80
AVFHAVSMIA
90
FKLDEDLCAA
100
PANGGNVSRP
110
PVTLRLVIPA
120
SQCGSLIGKA
130
GTKIKEIRET
140
TGAQVQVAGD
150
LLPNSTERAV
160
TVSGVPDAII
170
LCVRQICAVI
180
LESPPKGATI
190
PYHPSLSLGT
200
VLLSANQGFS
210
VQGQYGAVTP
220
AEVTKLQQLS
230
SHAVPFATPS
240
VVPGLDPGTQ
250
TSSQEFLVPN
260
DLIGCVIGRQ
270
GSKISEIRQM
280
SGAHIKIGNQ
290
AEGAGERHVT
300
ITGSPVSIAL
310
AQYLITACLE
320
TAKSTSGGTP
330
SSAPADLPAP
340
FSPPLTALPT
350
APPGLLGTPY
360
AISLSNFIGL
370
KPMPFLALPP
380
ASPGPPPGLA
390
AYTAKMAAAN
400
GSKKAERQKF
SPY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003730 | mRNA 3'-UTR binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.