Search Results
Overview
| Uniprot ID | P57737 |
|---|---|
| Protein Name | Coronin-7 |
| Gene Name | CORO7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 348 | IGYHVPRKAVEFHED |
Function
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology
Protein Sequence
10
MNRFRVSKFR
20
HTEARPPRRE
30
SWISDIRAGT
40
APSCRNHIKS
50
SCSLIAFNSD
60
RPGVLGIVPL
70
QGQGEDKRRV
80
AHLGCHSDLV
90
TDLDFSPFDD
100
FLLATGSADR
110
TVKLWRLPGP
120
GQALPSAPGV
130
VLGPEDLPVE
140
VLQFHPTSDG
150
ILVSAAGTTV
160
KVWDAAKQQP
170
LTELAAHGDL
180
VQSAVWSRDG
190
ALVGTACKDK
200
QLRIFDPRTK
210
PRASQSTQAH
220
ENSRDSRLAW
230
MGTWEHLVST
240
GFNQMREREV
250
KLWDTRFFSS
260
ALASLTLDTS
270
LGCLVPLLDP
280
DSGLLVLAGK
290
GERQLYCYEV
300
VPQQPALSPV
310
TQCVLESVLR
320
GAALVPRQAL
330
AVMSCEVLRV
340
LQLSDTAIVP
350
IGYHVPRKAV
360
EFHEDLFPDT
370
AGCVPATDPH
380
SWWAGDNQQV
390
QKVSLNPACR
400
PHPSFTSCLV
410
PPAEPLPDTA
420
QPAVMETPVG
430
DADASEGFSS
440
PPSSLTSPST
450
PSSLGPSLSS
460
TSGIGTSPSL
470
RSLQSLLGPS
480
SKFRHAQGTV
490
LHRDSHITNL
500
KGLNLTTPGE
510
SDGFCANKLR
520
VAVPLLSSGG
530
QVAVLELRKP
540
GRLPDTALPT
550
LQNGAAVTDL
560
AWDPFDPHRL
570
AVAGEDARIR
580
LWRVPAEGLE
590
EVLTTPETVL
600
TGHTEKICSL
610
RFHPLAANVL
620
ASSSYDLTVR
630
IWDLQAGADR
640
LKLQGHQDQI
650
FSLAWSPDGQ
660
QLATVCKDGR
670
VRVYRPRSGP
680
EPLQEGPGPK
690
GGRGARIVWV
700
CDGRCLLVSG
710
FDSQSERQLL
720
LYEAEALAGG
730
PLAVLGLDVA
740
PSTLLPSYDP
750
DTGLVLLTGK
760
GDTRVFLYEL
770
LPESPFFLEC
780
NSFTSPDPHK
790
GLVLLPKTEC
800
DVREVELMRC
810
LRLRQSSLEP
820
VAFRLPRVRK
830
EFFQDDVFPD
840
TAVIWEPVLS
850
AEAWLQGANG
860
QPWLLSLQPP
870
DMSPVSQAPR
880
EAPARRAPSS
890
AQYLEEKSDQ
900
QKKEELLNAM
910
VAKLGNREDP
920
LPQDSFEGVD
EDEWD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030041 | actin filament polymerization |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0006895 | Golgi to endosome transport |
| Biological Process | GO:0035332 | positive regulation of hippo signaling |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.