Search Results

Overview

Uniprot IDP58107
Protein NameEpiplakin
Gene NameEPPK1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2234 AGVLVPAKDQPGRQE

Function

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:23398049, PubMed:27206504). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:23398049, PubMed:27206504). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity)

Protein Sequence

10 MSGHTLPPLP 20 VPGTNSTEQA 30 SVPRAMAATL 40 GAGTPPRPQA 50 RSIAGVYVEA 60 SGQAQSVYAA 70 MEQGLLPAGL 80 GQALLEAQAA 90 TGGLVDLARG 100 QLLPVSKALQ 110 QGLVGLELKE 120 KLLAAERATT 130 GYPDPYGGEK 140 LALFQAIGKE 150 VVDRALGQSW 160 LEVQLATGGL 170 VDPAQGVLVA 180 PEPACHQGLL 190 DRETWHKLSE 200 LEPGTGDLRF 210 LDPNTLERLT 220 YHQLLERCVR 230 APGSGLALLP 240 LKITFRSMGG 250 AVSAAELLEV 260 GILDEQAVQG 270 LREGRLAAVD 280 VSARAEVRRY 290 LEGTGSVAGV 300 VLLPEGHKKS 310 FFQAATEHLL 320 PMGTALPLLE 330 AQAATHTLVD 340 PITGQRLWVD 350 EAVRAGLVSP 360 ELHEQLLVAE 370 QAVTGHHDPF 380 SGSQIPLFQA 390 MKKGLVDRPL 400 ALRLLDAQLA 410 TGGLVCPARR 420 LRLPLEAALR 430 CGCLDEDTQR 440 QLSQAGSFSD 450 GTHGGLRYEQ 460 LLALCVTDPE 470 TGLAFLPLSG 480 GPRGGEPQGP 490 PFIKYSTRQA 500 LSTATATVSV 510 GKFRGRPVSL 520 WELLFSEAIS 530 SEQRAMLAQQ 540 YQEGTLSVEK 550 LAAKLSATLE 560 QAAATARVTF 570 SGLRDTVTPG 580 ELLKAEIIDQ 590 DLYERLEHGQ 600 ATAKDVGSLA 610 SVQRYLQGTG 620 CIAGLLLPGS 630 QERLSIYEAR 640 CKGLLRPGTA 650 LILLEAQAAT 660 GFIIDPKANK 670 GHSVEEALRA 680 AVIGPDVFAK 690 LLSAERAVTG 700 YTDPYTGQQI 710 SLFQAMQKGL 720 IVREHGIRLL 730 EAQIATGGVI 740 DPVHSHRVPV 750 DVAYRRGYFD 760 QMLNLILLDP 770 SDDTKGFFDP 780 NTHENLTYLQ 790 LLERCVRDPE 800 TGLYLLPLSS 810 TQSPLVDSAT 820 QQAFQNLLLS 830 VKYGRFQGQR 840 VSAWELINSE 850 YFSEGRRRQL 860 LRRYRQREVT 870 LGQVAKLLEA 880 ETQRQADIML 890 PALRSRVTVH 900 QLLEAGIIDQ 910 QLLDQVLAGT 920 ISPEALLLMD 930 GVRRYLCGLG 940 AVGGVRLLPS 950 GQRLSLYQAM 960 RQKLLGPRVA 970 LALLEAQAAT 980 GTIMDPHSPE 990 SLSVDEAVRR 1000 GVVGPELYGR 1010 LKRAEGAIAG 1020 FRDPFSGKQV 1030 SVFQAMKKGL 1040 IPWEQAARLL 1050 EAQVATGGII 1060 DPTSHHHLPM 1070 PVAIQRGYVD 1080 QEMETALSSS 1090 SETFPTPDGQ 1100 GRTSYAQLLE 1110 ECPRDETSGL 1120 HLLPLPESAP 1130 ALPTEEQVQR 1140 SLQAVPGAKD 1150 GTSLWDLLSS 1160 CHFTEEQRRG 1170 LLEDVQEGRT 1180 TVPQLLASVQ 1190 RWVQETKLLA 1200 QARVMVPGPR 1210 GEVPAVWLLD 1220 AGIITQETLE 1230 ALAQGTQSPA 1240 QVAEQPAVKA 1250 CLWGTGCVAG 1260 VLLQPSGAKA 1270 SIAQAVRDGL 1280 LPTGLGQRLL 1290 EAQVASGFLV 1300 DPLNNQRLSV 1310 EDAVKVGLVG 1320 RELSEQLGQA 1330 ERAAAGYPDP 1340 YSRASLSLWQ 1350 AMEKGLVPQN 1360 EGLPLLQVQL 1370 ATGGVVDPVH 1380 GVHLPQAAAC 1390 RLGLLDTQTS 1400 QVLTAVDKDN 1410 KFFFDPSARD 1420 QVTYQQLRER 1430 CVCDSETGLL 1440 LLPLPSDTVL 1450 EVDDHTAVAL 1460 RAMKVPVSTG 1470 RFKGCSVSLW 1480 DLLLSEYVGA 1490 DKRRELVALC 1500 RSGRAAALRQ 1510 VVSAVTTLVE 1520 AAERQPLQAT 1530 FRGLRKQVSA 1540 RDLFRAQLIS 1550 RKTLDELSQG 1560 TTTVKEVAEM 1570 DSVKRSLEGG 1580 NFIAGVLIQG 1590 TQERMSIPEA 1600 LRRHILRPGT 1610 ALVLLEAQAA 1620 TGFIIDPVEN 1630 RKLTVEEAFK 1640 AGMFGKETYV 1650 KLLSAERAVT 1660 GYTDPYTGQQ 1670 ISLFQAMQKD 1680 LIVREHGIRL 1690 LEAQIATGGI 1700 IDPVHSHRVP 1710 VDVAYRCGYF 1720 DEEMNRILAD 1730 PSDDTKGFFD 1740 PNTHENLTYL 1750 QLLERCVEDP 1760 ETGLYLLQII 1770 KKGENYVYIN 1780 EATRHVLQSR 1790 TAKMRVGRFA 1800 DQVVSFWDLL 1810 SSPYFTEDRK 1820 RELIQEYGAQ 1830 SGGLEKLLEI 1840 ITTTIEETET 1850 QNQGIKVAAI 1860 RGEVTAADLF 1870 NSRVIDQKTL 1880 HTLRVGRTGG 1890 QALSTLECVK 1900 PYLEGSGCIA 1910 GVTVPSTREV 1920 MSLHEASRKE 1930 LIPAAFATWL 1940 LEAQAATGFL 1950 LDPCTRQKLS 1960 VDEAVDVGLV 1970 NEELRERLLK 1980 AERAATGYRD 1990 PATGDTIPLF 2000 QAMQKQLIEK 2010 AEALRLLEVQ 2020 VATGGVIDPQ 2030 HHHRLPLETA 2040 YRRGCLHKDI 2050 YALISDQKHM 2060 RKRFVDPNTQ 2070 EKVSYRELQE 2080 RCRPQEDTGW 2090 LLFPVNKAAR 2100 DSEHIDDETR 2110 RALEAEQVEI 2120 TVGRFRGQKP 2130 TLWALLNSEY 2140 VTEEKKLQLV 2150 RMYRTHTRRA 2160 LQTVAQLILE 2170 LIEKQETSNK 2180 HLWFQGIRRQ 2190 ITASELLSSA 2200 IITEEMLQDL 2210 ETGRSTTQEL 2220 MEDDRVKRYL 2230 EGTSCIAGVL 2240 VPAKDQPGRQ 2250 EKMSIYQAMW 2260 KGVLRPGTAL 2270 VLLEAQAATG 2280 FVIDPVRNLR 2290 LSVEEAVAAG 2300 VVGGEIQEKL 2310 LSAERAVTGY 2320 TDPYTGQQIS 2330 LFQAMQKDLI 2340 VREHGIRLLE 2350 AQIATGGVID 2360 PVHSHRVPVD 2370 VAYRRGYFDE 2380 EMNRVLADPS 2390 DDTKGFFDPN 2400 THENLTYVQL 2410 LRRCVPDPDT 2420 GLYMLQLAGR 2430 GSAVHQLSEE 2440 LRCALRDARV 2450 TPGSGALQGQ 2460 SVSVWELLFY 2470 REVSEDRRQD 2480 LLSRYRAGTL 2490 TVEELGATLT 2500 SLLAQAQAQA 2510 RAEAEAGSPR 2520 PDPREALRAA 2530 TMEVKVGRLR 2540 GRAVPVWDVL 2550 ASGYVSRAAR 2560 EELLAEFGSG 2570 TLDLPALTRR 2580 LTAIIEEAEE 2590 APGARPQLQD 2600 AWRGPREPGP 2610 AGRGDGDSGR 2620 SQREGQGEGE 2630 TQEAAAAAAA 2640 AAARRQEQTL 2650 RDATMEVQRG 2660 QFQGRPVSVW 2670 DVLFSSYLSE 2680 ARRDELLAQH 2690 AAGALGLPDL 2700 VAVLTRVIEE 2710 TEERLSKVSF 2720 RGLRRQVSAS 2730 ELHTSGILGP 2740 ETLRDLAQGT 2750 KTLQEVTEMD 2760 SVKRYLEGTS 2770 CIAGVLVPAK 2780 DQPGRQEKMS 2790 IYQAMWKGVL 2800 RPGTALVLLE 2810 AQAATGFVID 2820 PVRNLRLSVE 2830 EAVAAGVVGG 2840 EIQEKLLSAE 2850 RAVTGYTDPY 2860 TGQQISLFQA 2870 MQKDLIVREH 2880 GIRLLEAQIA 2890 TGGVIDPVHS 2900 HRVPVDVAYQ 2910 RGYFDEEMNR 2920 VLADPSDDTK 2930 GFFDPNTHEN 2940 LTYVQLLRRC 2950 VPDPDTGLYM 2960 LQLAGRGSAV 2970 HQLSEELRCA 2980 LRDARVTPGS 2990 GALQGQSVSV 3000 WELLFYREVS 3010 EDRRQDLLSR 3020 YRAGTLTVEE 3030 LGATLTSLLA 3040 QAQAQARAEA 3050 EAGSPRPDPR 3060 EALRAATMEV 3070 KVGRLRGRAV 3080 PVWDVLASGY 3090 VSRAAREELL 3100 AEFGSGTLDL 3110 PALTRRLTAI 3120 IEEAEEAPGA 3130 RPQLQDAWRG 3140 PREPGPAGRG 3150 DGDSGRSQRE 3160 GQGEGETQEA 3170 AAAARRQEQT 3180 LRDATMEVQR 3190 GQFQGRPVSV 3200 WDVLFSSYLS 3210 EARRDELLAQ 3220 HAAGALGLPD 3230 LVAVLTRVIE 3240 ETEERLSKVS 3250 FRGLRCQVSA 3260 SELHTSGILG 3270 PETLRDLAQG 3280 TKTLQEVTEM 3290 DSVKRYLEGT 3300 SCIAGVLVPA 3310 KDQPGRQEKM 3320 SIYQAMWKGV 3330 LRPGTALVLL 3340 EAQAATGFVI 3350 DPVRNLRLSV 3360 EEAVAAGVVG 3370 GEIQEKLLSA 3380 ERAVTGYTDP 3390 YTGQQISLFQ 3400 AMQKDLIVRE 3410 HGIRLLEAQI 3420 ATGGVIDPVH 3430 SHRVPVDVAY 3440 RRGYFDEEMN 3450 RVLADPSDDT 3460 KGFFDPNTHE 3470 NLTYVQLLRR 3480 CVPDPDTGLY 3490 MLQLAGRGSA 3500 VHQLSEELRC 3510 ALRDARVTPG 3520 SGALQGQSVS 3530 VWELLFYREV 3540 SEDRRQDLLS 3550 RYRAGTLTVE 3560 ELGATLTSLL 3570 AQAQAQARAE 3580 AEAGSPRPDP 3590 REALRAATME 3600 VKVGRLRGRA 3610 VPVWDVLASG 3620 YVSRAAREEL 3630 LAEFGSGTLD 3640 LPALTRRLTA 3650 IIEEAEEAPG 3660 ARPQLQDAWR 3670 GPREPGPAGR 3680 GDGDSGRSQR 3690 EGQGEGETQE 3700 AAAATAAARR 3710 QEQTLRDATM 3720 EVQRGQFQGR 3730 PVSVWDVLFS 3740 SYLSEARRDE 3750 LLAQHAAGAL 3760 GLPDLVAVLT 3770 RVIEETEERL 3780 SKVSFRGLRR 3790 QVSASELHTS 3800 GILGPETLRD 3810 LAQGTKTLQE 3820 VTEMDSVKRY 3830 LEGTSCIAGV 3840 LVPAKDQPGR 3850 QEKMSIYQAM 3860 WKGVLRPGTA 3870 LVLLEAQAAT 3880 GFVIDPVRNL 3890 RLSVEEAVAA 3900 GVVGGEIQEK 3910 LLSAERAVTG 3920 YTDPYTGQQI 3930 SLFQAMQKDL 3940 IVREHGIRLL 3950 EAQIATGGVI 3960 DPVHSHRVPV 3970 DVAYRRGYFD 3980 EEMNRVLADP 3990 SDDTKGFFDP 4000 NTHENLTYVQ 4010 LLRRCVPDPD 4020 TGLYMLQLAG 4030 RGSAVHQLSE 4040 ELRCALRDAR 4050 VTPGSGALQG 4060 QSVSVWELLF 4070 YREVSEDRRQ 4080 DLLSRYRAGT 4090 LTVEELGATL 4100 TSLLAQAQAQ 4110 ARAEAEAGSP 4120 RPDPREALRA 4130 ATMEVKVGRL 4140 RGRAVPVWDV 4150 LASGYVSRAA 4160 REELLAEFGS 4170 GTLDLPALTR 4180 RLTAIIEEAE 4190 EAPGARPQLQ 4200 DAWRGPREPG 4210 PAGRGDGDSG 4220 RSQREGQGEG 4230 ETQEAAAATA 4240 AARRQEQTLR 4250 DATMEVQRGQ 4260 FQGRPVSVWD 4270 VLFSSYLSEA 4280 RRDELLAQHA 4290 AGALGLPDLV 4300 AVLTRVIEET 4310 EERLSKVSFR 4320 GLRRQVSASE 4330 LHTSGILGPE 4340 TLRDLAQGTK 4350 TLQEVTEMDS 4360 VKRYLEGTSC 4370 IAGVLVPAKD 4380 QPGHQEKMSI 4390 YQAMWKGVLR 4400 PGTALVLLEA 4410 QAATGFVIDP 4420 VRNLRLSVEE 4430 AVAAGVVGGE 4440 IQEKLLSAER 4450 AVTGYTDPYT 4460 GQQISLFQAM 4470 QKDLIVREHG 4480 IRLLEAQIAT 4490 GGVIDPVHSH 4500 RVPVDVAYRR 4510 GYFDEEMNRV 4520 LAHPSDDTKG 4530 FFDPNTHENL 4540 TYVQLLRRCV 4550 PDPDTGLYML 4560 QLAGRGSAVH 4570 QLSEELRCAL 4580 RDARVMPGSG 4590 ALQGQSVSVW 4600 ELLFYREVSE 4610 DRRQDLLSRY 4620 RAGTLTVEEL 4630 GATLTSLLAQ 4640 AQAQARAEAE 4650 AEAGSPRPDP 4660 REALRAATME 4670 VKVGRLRGRA 4680 VPVWDVLASG 4690 YVSGAAREEL 4700 LAEFGSGTLD 4710 LPALTRRLTA 4720 IIEEAEEAPG 4730 ARPQLQDAWR 4740 GPREPGPAGR 4750 GDGDSGRSQR 4760 EGQGEGETQE 4770 AAAAARRQEQ 4780 TLRDATMEVQ 4790 RGQFQGRPVS 4800 VWDVLFSSYL 4810 SEAHRDELLA 4820 QHAAGALGLP 4830 DLVAVLTRVI 4840 EETEERLSKV 4850 SFRGLRRQVS 4860 ASELHTSGIL 4870 GPETLRDLAQ 4880 GTKTLQEVTE 4890 MDSVKRYLEG 4900 TSCIAGVLVP 4910 AKDQPGRQEK 4920 MSIYQAMWKG 4930 VLRPGTALVL 4940 LEAQAATGFV 4950 IDPVRNLRLS 4960 VEEAVAAGVV 4970 GGEIQEKLLS 4980 AERAVTGYTD 4990 PYTGQQISLF 5000 QAMQKDLIVR 5010 EHGIRLLEAQ 5020 IATGGVIDPV 5030 HSHRVPVDVA 5040 YRRGYFDEEM 5050 NRVLADPSDD 5060 TKGFFDPNTH 5070 ENLTYLQLLQ 5080 RATLDPETGL LFLSLSLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0030054 cell junction
Cellular Component GO:0071944 cell periphery
Cellular Component GO:0042995 cell projection
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0030056 hemidesmosome
Cellular Component GO:0045111 intermediate filament cytoskeleton
Cellular Component GO:0045095 keratin filament
Cellular Component GO:0016020 membrane
Cellular Component GO:0097356 perinucleolar compartment
Molecular Function GO:0019215 intermediate filament binding
Molecular Function GO:1990254 keratin filament binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0045110 intermediate filament bundle assembly
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0051548 negative regulation of keratinocyte migration
Biological Process GO:0010839 negative regulation of keratinocyte proliferation
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:1905041 regulation of epithelium regeneration
Biological Process GO:0042060 wound healing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.